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GlutaryllipoH2-K110-DLST [mitochondrial matrix]
Stable Identifier
R-HSA-9858581
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
DLST
Locations in the PathwayBrowser for interactor UniProt:Q96EF9 ZHX1R
Expand all
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Lysine catabolism (Homo sapiens)
OADH complex synthesizes glutaryl-CoA from 2-OA (Homo sapiens)
DHTKD1 dimer decarboxylates 2-OA (Homo sapiens)
GlutaryllipoH2-K110-DLST [mitochondrial matrix] (Homo sapiens)
DLST transfers glutaryl to CoA (Homo sapiens)
GlutaryllipoH2-K110-DLST [mitochondrial matrix] (Homo sapiens)
External Reference Information
External Reference
UniProt:P36957 DLST
Gene Names
DLST, DLTS
Chain
transit peptide:1-67, chain:68-453
Reference Genes
BioGPS Gene:1743 DLST
COSMIC (genes):DLST DLST
CTD Gene:1743 DLST
dbSNP Gene:1743 DLST
ENSEMBL:ENSG00000119689 DLST
ENSEMBL_homo_sapiens_GENE:ENSG00000119689.15 DLST
HGNC:2911 DLST
KEGG Gene (Homo sapiens):1743 DLST
Monarch:1743 DLST
NCBI Gene:1743 DLST
OMIM:126063 DLST
UCSC:P36957 DLST
Reference Transcript
RefSeq:NM_001933.4 DLST
Other Identifiers
11720929_a_at
11720930_s_at
11720931_x_at
11720932_s_at
11748080_a_at
11751226_x_at
16786524
1743
215210_PM_s_at
215210_s_at
2418675
2418678
2418682
33257_at
33258_g_at
3544351
3544352
3544353
3544354
3544355
3544356
3544358
3544360
3544363
3544364
3544365
3544367
3544369
3544370
3544372
3544373
3544374
3544375
3544376
3544377
3544378
3544379
3544380
3544381
45545_at
7975747
A_14_P109426
A_24_P13572
D26535_s_at
GE61495
GO:0003824
GO:0004149
GO:0005515
GO:0005634
GO:0005654
GO:0005739
GO:0005759
GO:0005829
GO:0006091
GO:0006099
GO:0006103
GO:0006104
GO:0006520
GO:0006790
GO:0016020
GO:0016740
GO:0016746
GO:0033512
GO:0036211
GO:0043226
GO:0045252
GO:0055086
GO:0106077
GO:0140096
GO:1901135
GO:1990204
HMNXSV003018081
HMNXSV003048834
Hs.296348.0.S1_3p_s_at
ILMN_1773228
PH_hs_0029663
PH_hs_0032549
TC14000465.hg
TC14001772.hg
Participates
as an output of
DHTKD1 dimer decarboxylates 2-OA (Homo sapiens)
as an input of
DLST transfers glutaryl to CoA (Homo sapiens)
Other forms of this molecule
Lipo-K110-DLST [mitochondrial matrix]
SuccinyllipoH2-K110-DLST [mitochondrial matrix]
LipoH2-K110-DLST [mitochondrial matrix]
DLST [mitochondrial matrix]
Inferred To
KGD2 [mitochondrial matrix]
(Saccharomyces cerevisiae)
odhB [mitochondrial matrix]
(Dictyostelium discoideum)
dlst-1 [mitochondrial matrix]
(Caenorhabditis elegans)
DLST [mitochondrial matrix]
(Bos taurus)
DLST [mitochondrial matrix]
(Canis familiaris)
DLST [mitochondrial matrix]
(Gallus gallus)
DLST [mitochondrial matrix]
(Sus scrofa)
GlutaryllipoH2-K110-DLST [mitochondrial matrix]
(Plasmodium falciparum)
Dlst [mitochondrial matrix]
(Drosophila melanogaster)
Dlst [mitochondrial matrix]
(Mus musculus)
Dlst [mitochondrial matrix]
(Rattus norvegicus)
kgd2 [mitochondrial matrix]
(Schizosaccharomyces pombe)
dlst [mitochondrial matrix]
(Danio rerio)
dlst [mitochondrial matrix]
(Xenopus tropicalis)
Modified Residues
Name
N6-lipoyl-L-lysine ((R)-N6-(S8-glutaryldihydrolipoyl)-L-lysine(1−) residue) at 110
Coordinate
110
Modification
(R)-N6-(S8-glutaryldihydrolipoyl)-L-lysine(1−) residue
PsiMod Name
N6-lipoyl-L-lysine [MOD:00127]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-lipoyl-L-lysine.
Cross References
RefSeq
NP_001924.2
OpenTargets
ENSG00000119689
IntEnz
2.3.1.61
HPA
ENSG00000119689-DLST
GeneCards
P36957
Ensembl
ENSG00000119689
,
ENSP00000335304
,
ENST00000334220
PRO
P36957
Pharos - Targets
P36957
PDB
6H05
HMDB Protein
HMDBP00939
Interactors (81)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P43686 PSMC4
2
PSMC4 [nucleoplasm]
(R-HSA-174315)
PSMC4 [cytosol]
(R-HSA-68777)
0.666
5
UniProt:Q96EF9 ZHX1R
0.556
3
UniProt:Q68CL5-3 TPGS2
0.556
3
UniProt:P09471 GNAO1
1
GNAO1 [plasma membrane]
(R-HSA-2997536)
0.556
3
UniProt:O75175 CNOT3
1
CNOT3 [cytosol]
(R-HSA-429872)
0.556
3
UniProt:Q9NX07 TSAP1
0.556
3
UniProt:Q7Z698 SPRED2
2
SPRED2 [cytosol]
(R-HSA-5654211)
SPRED2 [plasma membrane]
(R-HSA-5658229)
0.556
3
IntAct:EBI-25833913 CCSB
0.556
3
UniProt:Q3SY56 SP6
0.556
3
IntAct:EBI-25831691 CCSB
0.556
3
UniProt:Q96E17 RAB3C
2
GGC-RAB3C [cytosol]
(R-HSA-8874012)
RAB3C [cytosol]
(R-HSA-8873684)
0.556
3
UniProt:Q9NVM1 EVA1B
0.556
3
UniProt:O94983-5 CAMTA2
0.556
3
UniProt:Q9HC98-4 NEK6
0.556
3
UniProt:P36382 GJA5
1
GJA5 [endoplasmic reticulum membrane]
(R-HSA-190648)
0.556
3
UniProt:Q7Z780 Q7Z780
0.556
3
UniProt:Q96GK7 FAH2A
0.556
3
UniProt:Q8TAB5 CA216
0.556
3
UniProt:Q02978 SLC25A11
1
SLC25A11 [mitochondrial inner membrane]
(R-HSA-198451)
0.556
3
UniProt:P49184 DNASE1L1
2
DNASE1L1 [extracellular region]
(R-HSA-6806320)
DNASE1L1 [specific granule lumen]
(R-HSA-6799554)
0.556
3
UniProt:Q96L03 SPT17
0.556
3
UniProt:Q9H2S6-2 TNMD
0.556
3
UniProt:F6Y2X3 F6Y2X3
0.556
3
UniProt:Q96I25 RBM17
1
RBM17 [nucleoplasm]
(R-HSA-8865891)
0.556
3
UniProt:A2RUH7 MBPHL
0.556
3
UniProt:Q9BT49 THAP7
0.556
3
UniProt:Q8N1W1-4 ARHGEF28
0.556
3
UniProt:Q9Y617 PSAT1
1
PXLP-K200-PSAT1 [cytosol]
(R-HSA-977330)
0.556
3
UniProt:Q9BQ29 Q9BQ29
0.556
3
UniProt:Q8TB02 Q8TB02
0.556
3
UniProt:P43356 MAGA2
0.556
3
UniProt:Q96JJ7-2 Q96JJ72
0.556
3
UniProt:P14060 HSD3B1
1
HSD3B1 [endoplasmic reticulum membrane]
(R-HSA-192072)
0.556
3
UniProt:P79483 HLA-DRB3
9
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [lumenal side of endoplasmic reticulum membrane]
(R-HSA-2130513)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [ER to Golgi transport vesicle membrane]
(R-HSA-2130432)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [Golgi membrane]
(R-HSA-2214381)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [trans-Golgi network membrane]
(R-HSA-2130452)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [transport vesicle membrane]
(R-HSA-2130559)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130515)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [endocytic vesicle membrane]
(R-HSA-2130377)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [lysosomal membrane]
(R-HSA-2130676)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [plasma membrane]
(R-HSA-197577)
0.556
3
UniProt:Q6P4D5-2 PABIR3
0.556
3
UniProt:Q6P5S2 LEG1H
0.556
3
UniProt:O75317 USP12
1
USP12 [nucleoplasm]
(R-HSA-5696907)
0.556
3
IntAct:EBI-25834143 CCSB
0.556
3
IntAct:EBI-25833532 RZPDO839F06154
0.556
3
UniProt:O75874 IDH1
10
IDH1 R132H mutant [cytosol]
(R-HSA-880015)
IDH1 R132L mutant [cytosol]
(R-HSA-880000)
IDH1 R132S mutant [cytosol]
(R-HSA-880048)
IDH1 R132C mutant [cytosol]
(R-HSA-880031)
IDH1 [secretory granule lumen]
(R-HSA-6800980)
IDH1 [ficolin-1-rich granule lumen]
(R-HSA-6800977)
IDH1 [extracellular region]
(R-HSA-6806433)
IDH1 [tertiary granule lumen]
(R-HSA-6800163)
IDH1 [cytosol]
(R-HSA-389549)
IDH1 [peroxisomal matrix]
(R-HSA-389546)
0.556
3
UniProt:Q13636 RAB31
5
GGC-RAB31 [early endosome membrane]
(R-HSA-8877278)
GGC-RAB31 [cytosol]
(R-HSA-8873974)
RAB31 [cytosol]
(R-HSA-8873690)
RAB31 [plasma membrane]
(R-HSA-6804813)
RAB31 [secretory granule membrane]
(R-HSA-6804797)
0.556
3
UniProt:Q8NBT0 POC1A
0.556
3
UniProt:Q96EY8 MMAB
4
MMAB E193K [mitochondrial matrix]
(R-HSA-3322150)
MMAB R191W [mitochondrial matrix]
(R-HSA-3322112)
MMAB R186W [mitochondrial matrix]
(R-HSA-3322128)
MMAB [mitochondrial matrix]
(R-HSA-2980970)
0.556
3
UniProt:P49746 THBS3
1
THBS3 [extracellular region]
(R-HSA-66522)
0.556
3
UniProt:P48775 TDO2
1
TDO2 [cytosol]
(R-HSA-71184)
0.556
3
UniProt:A0JP07 A0JP07
0.556
3
UniProt:O00214-2 LGALS8
0.556
3
UniProt:Q9ULR0 ISY1
1
ISY1 [nucleoplasm]
(R-HSA-6781963)
0.556
3
UniProt:Q9Y3Y4 PYGO1
1
PYGO1 [nucleoplasm]
(R-HSA-201705)
0.556
3
UniProt:Q96QH2 PRAM
0.556
3
UniProt:O14829 PPEF1
1
PPEF1 [cytosol]
(R-HSA-2632517)
0.556
3
UniProt:Q99944 EGFL8
0.556
3
UniProt:Q8NCF5-2 NFATC2IP
0.556
3
UniProt:P50749 RASF2
0.556
3
UniProt:Q8NCR3 MFI
0.556
3
UniProt:P09382 LGALS1
2
p-LGALS1 [endoplasmic reticulum lumen]
(R-HSA-8957003)
LGALS1 [endoplasmic reticulum lumen]
(R-HSA-8956711)
0.556
3
IntAct:EBI-25833762 CCSB
0.556
3
IntAct:EBI-25833683 CCSB
0.556
3
UniProt:Q8IY82 DRC7
0.556
3
UniProt:Q9NPC7 MYNN
0.556
3
UniProt:Q8N323 NXPE1
0.556
3
UniProt:Q6UXH1-2 CRELD2
0.556
3
UniProt:Q7Z6Z7-2 HUWE1
0.556
3
UniProt:P52756 RBM5
1
RBM5 [nucleoplasm]
(R-HSA-72049)
0.556
3
UniProt:P61224 RAP1B
2
RAP1B [azurophil granule membrane]
(R-HSA-6804972)
RAP1B [plasma membrane]
(R-HSA-377590)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:Q13200 PSMD2
5
PSMD2 [secretory granule lumen]
(R-HSA-6800919)
PSMD2 [extracellular region]
(R-HSA-6806479)
PSMD2 [ficolin-1-rich granule lumen]
(R-HSA-6800435)
PSMD2 [nucleoplasm]
(R-HSA-174311)
PSMD2 [cytosol]
(R-HSA-68796)
0.556
3
UniProt:P16422 EPCAM
1
EPCAM [plasma membrane]
(R-HSA-375068)
0.556
3
UniProt:P26715 KLRC1
1
KLRC1 [plasma membrane]
(R-HSA-3006545)
0.556
3
UniProt:Q9ULW0 TPX2
2
TPX2 [cytosol]
(R-HSA-8853407)
TPX2 [nucleoplasm]
(R-HSA-2564700)
0.556
3
UniProt:Q7Z434 MAVS
2
MAVS [mitochondrial outer membrane]
(R-HSA-913730)
K48polyUb-MAVS [mitochondrial outer membrane]
(R-HSA-983463)
0.556
3
UniProt:P07437 TUBB
3
TUBB [cytosol]
(R-HSA-9020816)
TUBB [azurophil granule lumen]
(R-HSA-6799370)
TUBB [extracellular region]
(R-HSA-380317)
0.556
3
UniProt:Q10981 FUT2
1
FUT2 [Golgi membrane]
(R-HSA-2980904)
0.556
3
UniProt:Q96P20 NLRP3
2
K63polyUb-NLRP3 [cytosol]
(R-HSA-6783288)
NLRP3 [cytosol]
(R-HSA-561189)
0.556
3
UniProt:Q8N2W9 PIAS4
2
PIAS4 [nucleoplasm]
(R-HSA-2993789)
monoSUMO1-K35-PIAS4 [nucleoplasm]
(R-HSA-3968415)
0.556
3
UniProt:P55209 NP1L1
0.547
3
UniProt:P09622 DLD
8
I47T DLD [mitochondrial matrix]
(R-HSA-9907707)
D479V DLD [mitochondrial matrix]
(R-HSA-9907708)
G229C DLD [mitochondrial matrix]
(R-HSA-9907709)
R495G DLD [mitochondrial matrix]
(R-HSA-9907710)
E375K DLD [mitochondrial matrix]
(R-HSA-9907711)
I393T DLD [mitochondrial matrix]
(R-HSA-9907713)
M361V DLD [mitochondrial matrix]
(R-HSA-9907714)
DLD [mitochondrial matrix]
(R-HSA-69978)
0.527
2
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.499
4
UniProt:P06493 CDK1
11
CDK1 [endoplasmic reticulum membrane]
(R-HSA-264424)
p-Y4-CDK1 [cytosol]
(R-HSA-9836187)
p-T14,T161-CDK1 [nucleoplasm]
(R-HSA-170078)
p-T14-CDK1 [nucleoplasm]
(R-HSA-170045)
p-T14-CDK1 [cytosol]
(R-HSA-170064)
CDK1 [nucleoplasm]
(R-HSA-68889)
CDK1 [cytosol]
(R-HSA-170075)
p-T14,Y15,T161-CDK1 [cytosol]
(R-HSA-170071)
p-T161-CDK1 [cytosol]
(R-HSA-157415)
p-T14,Y15,T161-CDK1 [nucleoplasm]
(R-HSA-170074)
p-T161-CDK1 [nucleoplasm]
(R-HSA-170066)
0.499
3
UniProt:Q9H9B4 SFXN1
0.483
3
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
8
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