MITF-M-dependent CDK2 expression

Stable Identifier
R-HSA-9858566
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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MITF-M-dependent CDK2 expression
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CDK2 is expressed in the melanocyte lineage and in melanoma cells in a manner that depends on MITF binding to E-box elements in its promoter (Du et al, 2004). CDK2 and MITF are coordinately expressed in many melanoma cell lines and CDK2 expression may contribute to the pro-proliferative effect of MITF (Du et al, 2004; Azimi et al, 2018; reviewed in Goding and Arnheiter, 2019).
Literature References
PubMed ID Title Journal Year
29507054 Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors

Azimi, A, Caramuta, S, Seashore-Ludlow, B, Boström, J, Robinson, JL, Edfors, F, Tuominen, R, Kemper, K, Krijgsman, O, Peeper, DS, Nielsen, J, Hansson, J, Egyhazi Brage, S, Altun, M, Uhlén, M, Maddalo, G

Mol Syst Biol 2018
31123060 MITF-the first 25 years

Goding, CR, Arnheiter, H

Genes Dev 2019
15607961 Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF

Du, J, Widlund, HR, Horstmann, MA, Ramaswamy, S, Ross, K, Huber, WE, Nishimura, EK, Golub, TR, Fisher, DE

Cancer Cell 2004
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
MITF-M dimer:CDK2 gene [nucleoplasm] (Homo sapiens)
Active Unit
MITF-M dimer [nucleoplasm]
Authored
Rothfels, K  (2023-12-21)
Reviewed
Arnheiter, H  (2024-02-26)
de la Serna, IL  (2024-05-21)
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Created
Rothfels, K  (2024-01-13)
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