MITF-M-dependent TRPM1 expression

Stable Identifier
R-HSA-9858297
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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TRPM1 encodes a cation channel that allows passages of various cations from the extracellular space into the cytoplasm (reviewed in Marini et al, 2023; Chubanov et al, 2023). TRPM1 has been identified as a direct target of MITF-M in melanocytes, retinal pigment epithelial cells and melanoma cells (Hunter et al, 1998; Miller et al, 2004; Miller et al, 2005; Strub et al, 2011). Expression is frequently downregulated during melanoma progression (Duncan et al, 1998; Duncan et al, 2001). The significance of TRPM1 downregulation in melanoma is unclear. Intron 6 of TRPM1 contains the MIR211 gene encoding microRNA miR-211 which is therefore similarly downregulated in melanoma. Targets of miR-211 include the MITF promoter binding protein POU3F2 (also known as BRN2), AP1S2, IGFBP5, SOX11 and SERINC3). How the changes in levels of TRPM1, miR-211 and miR-211 targets contribute to melanoma progression remains to be clarified (Margue et al, 2013; Levy et al, 2010; Boyle et al, 2011; De Luca et al, 2016; reviewed in Goding and Arnheiter, 2019).
Literature References
PubMed ID Title Journal Year
11208852 Melastatin expression and prognosis in cutaneous malignant melanoma

Kauffman, M, Deeds, J, Donovan, M, Sober, AJ, Duncan, LM, Cronin, FE, McCarthy, JJ

J Clin Oncol 2001
21109473 Intronic miR-211 assumes the tumor suppressive function of its host gene in melanoma

Scott, KL, Fletcher, AL, Song, JS, Li, S, Novina, CD, Yokoyama, S, Khaled, M, Turley, SJ, Fisher, DE, Levy, C, Garraway, LA, Iliopoulos, D, Pinner, S, Janas, MM, Chen, PH, Schubert, S, Granter, SR

Mol Cell 2010
14744763 Transcriptional regulation of the melanoma prognostic marker melastatin (TRPM1) by MITF in melanocytes and melanoma

Widlund, HR, Hershey, CL, Fisher, DE, Rowan, S, Du, J, Miller, AJ

Cancer Res 2004
31123060 MITF-the first 25 years

Arnheiter, H, Goding, CR

Genes Dev 2019
21435193 Melanoma cell invasiveness is regulated by miR-211 suppression of the BRN2 transcription factor

Sturm, RA, Hacker, E, Boyle, GM, Dutton-Regester, K, Stark, MS, Bonazzi, VF, Cook, AL, Woods, SL, Aoude, LG, Hayward, NK

Pigment Cell Melanoma Res 2011
37892239 TRP Channels in Cancer: Signaling Mechanisms and Translational Approaches

Geppetti, P, Souza Monteiro de Araújo, D, De Logu, F, Marini, M, Titiz, M, Nassini, R

Biomolecules 2023
9537257 Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis

Deeds, J, Shyjan, AW, Hunter, J, Shao, J, Duncan, LM, Holmgren, LM, Tepper, RI, Woolf, EA

Cancer Res 1998
37853091 TRPM channels in health and disease

Köttgen, M, Chubanov, V, Gudermann, T, Touyz, RM

Nat Rev Nephrol 2023
21258399 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma

Ye, T, Cormont, M, Keime, C, Kobi, D, Davidson, I, Le Gras, S, Giuliano, S, Bonet, C, Bertolotto, C, Ballotti, R, Strub, T

Oncogene 2011
15507434 Sumoylation of MITF and its related family members TFE3 and TFEB

Davis, IJ, Razin, E, Fisher, DE, Levy, C, Miller, AJ

J. Biol. Chem. 2005
9806836 Chromosomal localization and genomic characterization of the mouse melastatin gene (Mlsn1)

Moore, KJ, Shyjan, AW, Nagle, DL, Hunter, JJ, Smutko, JS, Shao, J, Holmgren, LM, Woolf, EA, Dussault, BJ

Genomics 1998
26599548 miR-211 and MITF modulation by Bcl-2 protein in melanoma cells

Trisciuoglio, D, Pelosi, A, Del Bufalo, D, Di Martile, M, Candiloro, A, Desideri, M, Farini, V, Bellei, B, Regazzo, G, Tupone, MG, De Luca, T, Rizzo, MG, D'Aguanno, S

Mol Carcinog 2016
24039954 New target genes of MITF-induced microRNA-211 contribute to melanoma cell invasion

Philippidou, D, Behrmann, I, Margue, C, Kreis, S, Schmitt, M, Reinsbach, SE

PLoS One 2013
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