MITF-M-dependent miR-211 expression

Stable Identifier
R-HSA-9858289
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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MITF-M-dependent miR-211 expression
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MIR211, encoding the microRNA miR-211 is an MITF-M-dependent target gene that is expressed in the melanocyte lineage and is frequently downregulated in melanoma (Hunter et al, 1998; Duncan et al, 1998; Duncan et al, 2001). The MIR211 gene falls in intron 6 of TRPM1, itself a direct MITF-M target, making MIR211 an co-transcriptional target (Miller et al, 2004; Miller et al, 2005; Strub et al, 2011). Both TRPM1 and miR-211 have been proposed as regulators of melanogenesis, but the precise roles played by each have not been clearly defined (Miler et al, 2004; Miller et al, 2005; Levy et al, 2010; Boyle et al, 2011; Margue et al, 2013; De Luca et al, 2016; reviewed in Goding and Arnheiter, 2019)
Genes regulated by miR-211 have diverse functions and disruption of expression of some of these target genes affects the invasiveness of melanoma cell lines (Levy et al, 2010; Boyle et al, 2011; Margue et al, 2013; De Luca et al, 2016). One miR-211 target is the transcription factor POU3F2 (also known as BRN2) which has been implicated in the regulation of MITF-M, establishing a feedback loop (Boyle et al, 2011; reviewed in Goding and Arnheiter, 2019; Fane et al, 2019).
Literature References
PubMed ID Title Journal Year
29781575 BRN2, a POUerful driver of melanoma phenotype switching and metastasis

Sturm, RA, Chhabra, Y, Fane, ME, Smith, AG

Pigment Cell Melanoma Res 2019
11208852 Melastatin expression and prognosis in cutaneous malignant melanoma

Kauffman, M, Deeds, J, Donovan, M, Sober, AJ, Duncan, LM, Cronin, FE, McCarthy, JJ

J Clin Oncol 2001
21109473 Intronic miR-211 assumes the tumor suppressive function of its host gene in melanoma

Scott, KL, Fletcher, AL, Song, JS, Li, S, Novina, CD, Yokoyama, S, Khaled, M, Turley, SJ, Fisher, DE, Levy, C, Garraway, LA, Iliopoulos, D, Pinner, S, Janas, MM, Chen, PH, Schubert, S, Granter, SR

Mol Cell 2010
14744763 Transcriptional regulation of the melanoma prognostic marker melastatin (TRPM1) by MITF in melanocytes and melanoma

Widlund, HR, Hershey, CL, Fisher, DE, Rowan, S, Du, J, Miller, AJ

Cancer Res 2004
21258399 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma

Ye, T, Cormont, M, Keime, C, Kobi, D, Davidson, I, Le Gras, S, Giuliano, S, Bonet, C, Bertolotto, C, Ballotti, R, Strub, T

Oncogene 2011
31123060 MITF-the first 25 years

Arnheiter, H, Goding, CR

Genes Dev 2019
21435193 Melanoma cell invasiveness is regulated by miR-211 suppression of the BRN2 transcription factor

Sturm, RA, Hacker, E, Boyle, GM, Dutton-Regester, K, Stark, MS, Bonazzi, VF, Cook, AL, Woods, SL, Aoude, LG, Hayward, NK

Pigment Cell Melanoma Res 2011
15507434 Sumoylation of MITF and its related family members TFE3 and TFEB

Davis, IJ, Razin, E, Fisher, DE, Levy, C, Miller, AJ

J. Biol. Chem. 2005
9537257 Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis

Deeds, J, Shyjan, AW, Hunter, J, Shao, J, Duncan, LM, Holmgren, LM, Tepper, RI, Woolf, EA

Cancer Res 1998
9806836 Chromosomal localization and genomic characterization of the mouse melastatin gene (Mlsn1)

Moore, KJ, Shyjan, AW, Nagle, DL, Hunter, JJ, Smutko, JS, Shao, J, Holmgren, LM, Woolf, EA, Dussault, BJ

Genomics 1998
26599548 miR-211 and MITF modulation by Bcl-2 protein in melanoma cells

Trisciuoglio, D, Pelosi, A, Del Bufalo, D, Di Martile, M, Candiloro, A, Desideri, M, Farini, V, Bellei, B, Regazzo, G, Tupone, MG, De Luca, T, Rizzo, MG, D'Aguanno, S

Mol Carcinog 2016
24039954 New target genes of MITF-induced microRNA-211 contribute to melanoma cell invasion

Philippidou, D, Behrmann, I, Margue, C, Kreis, S, Schmitt, M, Reinsbach, SE

PLoS One 2013
Participants
Input
Output
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as an event of
This event is regulated
Positively by
Regulator
MITF-M dimer:MIR211 gene [nucleoplasm] (Homo sapiens)
Active Unit
MITF-M dimer [nucleoplasm]
Authored
Rothfels, K  (2023-12-21)
Reviewed
de la Serna, IL  (2024-05-21)
Arnheiter, H  (2024-02-26)
Steingrímsson, E  (2024-11-05)
Vu, HN  (2024-11-05)
Created
Rothfels, K  (2024-01-10)
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