MITF-M dimer binds the TRPM1 gene

Stable Identifier
R-HSA-9858287
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MITF-M dimer binds the TRPM1 gene
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TRPM1 encodes a cation channel that transfers cations into the cytoplasm resulting in membrane depolarization. TRPM1 contains three E-boxes in its promoter that are bound by MITF-M to activate transcription, as assessed by ChIP, EMSA and reporter gene assay (Miller et al, 2004; Miller et al, 2005; Strub et al, 2011). Interestingly, non-sumoylatable MITF-M proteins with mutations at lysine residues 182 and 316 show a higher activity on a TRPM1 promoter construct provided it contains 3 E-boxes, but not when it contains only one E-box (Miller et al, 2005).
The gene for miR-211 is contained in an intron of TRPM1, making the miRNA a co-transcriptional target of MITF-M (Levy et al, 2010; reviewed in Goding and Arnheiter, 2019).
Literature References
PubMed ID Title Journal Year
14744763 Transcriptional regulation of the melanoma prognostic marker melastatin (TRPM1) by MITF in melanocytes and melanoma

Miller, AJ, Du, J, Rowan, S, Hershey, CL, Widlund, HR, Fisher, DE

Cancer Res 2004
21258399 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma

Strub, T, Giuliano, S, Ye, T, Bonet, C, Keime, C, Kobi, D, Le Gras, S, Cormont, M, Ballotti, R, Bertolotto, C, Davidson, I

Oncogene 2011
31123060 MITF-the first 25 years

Goding, CR, Arnheiter, H

Genes Dev 2019
15507434 Sumoylation of MITF and its related family members TFE3 and TFEB

Miller, AJ, Levy, C, Davis, IJ, Razin, E, Fisher, DE

J. Biol. Chem. 2005
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Authored
Rothfels, K  (2023-12-21)
Reviewed
Arnheiter, H  (2024-02-26)
de la Serna, IL  (2024-05-21)
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Created
Rothfels, K  (2024-01-10)
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