MITF-M dimer binds the BIRC7 promoter

Stable Identifier
R-HSA-9857359
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MITF-M dimer binds the BIRC7 promoter
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MITF-M binds to two consensus elements in the promoter of the BIRC7 gene in melanoma cell lines as assessed by ChIP and EMSA (Dynek et al, 2008; Strub et al, 2011). Stimulation of MITF-M with cAMP in melanocytes also causes upregulation of BIRC7 mRNA and protein levels (Dynek et al, 2008). BIRC7 is an anti-apoptotic protein, and consistent with this, melanoma cells show lower survival when MITF expression is ablated with siRNA (Dynek et al, 2008; reviewed in Saleem et al, 2013; Liu et al, 2007; Goding and Arnheiter, 2019).
Literature References
PubMed ID Title Journal Year
17218055 Livin/ML-IAP as a new target for cancer treatment

Liu, B, Han, M, Wen, JK, Wang, L

Cancer Lett 2007
21258399 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma

Strub, T, Giuliano, S, Ye, T, Bonet, C, Keime, C, Kobi, D, Le Gras, S, Cormont, M, Ballotti, R, Bertolotto, C, Davidson, I

Oncogene 2011
31123060 MITF-the first 25 years

Goding, CR, Arnheiter, H

Genes Dev 2019
23790005 Inhibitors of apoptotic proteins: new targets for anticancer therapy

Saleem, M, Qadir, MI, Perveen, N, Ahmad, B, Ahmad, B, Saleem, U, Irshad, T

Chem Biol Drug Des 2013
18451137 Microphthalmia-associated transcription factor is a critical transcriptional regulator of melanoma inhibitor of apoptosis in melanomas

Dynek, JN, Chan, SM, Liu, J, Zha, J, Fairbrother, WJ, Vucic, D

Cancer Res 2008
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Authored
Rothfels, K  (2023-12-21)
Reviewed
Arnheiter, H  (2024-02-26)
de la Serna, IL  (2024-05-21)
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Created
Rothfels, K  (2024-01-04)
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