Reactive oxygen species oxidize DNAJA1

Stable Identifier
R-HSA-9857090
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
3/5
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Reactive oxygen species oxidize DNAJA1
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Reactive oxygen species produced due to the presence of unfolded proteins in the mitochondrial matrix oxidize two cysteine residues (cysteine-149 and cysteine-150) on DNAJA1 (Sutandy et al. 2023). The nature of the oxidized cysteine residues (sulfenic, sulfinic, sulfonic) is unknown. Reactive oxygen species are required to activate the mitochondrial unfolded protein response (Sutandy et al. 2023).
Literature References
PubMed ID Title Journal Year
37286597 A cytosolic surveillance mechanism activates the mitochondrial UPR

Tascher, G, Gößner, I, Münch, C, Sutandy, FXR

Nature 2023
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Authored
May, B  (2023-12-30)
Created
May, B  (2023-12-31)
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