ATF5 and HSF1 trimer bind the HSPA9 gene

Stable Identifier
R-HSA-9857083
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
3/5
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ATF5 and HSF1 trimer bind the HSPA9 gene
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Both HSF1 and ATF5 bind the promoter of the HSPA9 gene (mt-HSP70 gene) after unfolded proteins accumulate in the mitochondrial matrix (Sutandy et al. 2023, the presence of HSF1 at the HSPA9 promoter is also inferred from mouse homologs in Katiyar et al. 2020).
Literature References
PubMed ID Title Journal Year
37286597 A cytosolic surveillance mechanism activates the mitochondrial UPR

Tascher, G, Gößner, I, Münch, C, Sutandy, FXR

Nature 2023
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as an event of
Authored
May, B  (2023-12-30)
Created
May, B  (2023-12-31)
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