ATF5 activates expression of DEFA5

Stable Identifier
R-HSA-9856669
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, Golgi lumen
ReviewStatus
3/5
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ATF5 activates expression of DEFA5
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During the mitochondrial response to unfolded protein (mtUPR), a reduction of mitochondrial protein import causes ATF5 to accumulate in the nucleus and activate expression of the extracellular defensin DEFA5 (HD-5) (Fiorese et al. 2016).
Literature References
PubMed ID Title Journal Year
27426517 The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR

Rosin, N, Haynes, CM, Schulz, AM, Fiorese, CJ, Pellegrino, MW, Lin, YF

Curr Biol 2016
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Output
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This event is regulated
Positively by
Regulator
ATF5 [nucleoplasm] (Homo sapiens)
Authored
May, B  (2023-12-20)
Created
May, B  (2023-12-21)
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