FOXO3 activates expression of SOD2

Stable Identifier
R-HSA-9856665
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, mitochondrial matrix
ReviewStatus
3/5
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FOXO3 activates expression of SOD2
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During the response to unfolded proteins in mitochondria (mtUPR), FOXO3 that is activated by deacetylation translocates to the nucleus and activates expression of the manganese-type superoxide dismutase gene (SOD2 gene, MnSOD gene) (Papa and Germain 2014). FOXO3 may bind the promoter of the SOD2 gene, but this has not been assayed during mtUPR.
Literature References
PubMed ID Title Journal Year
24324009 SirT3 regulates the mitochondrial unfolded protein response

Papa, L, Germain, D

Mol Cell Biol 2014
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
FOXO3 [nucleoplasm] (Homo sapiens)
Active Unit
FOXO3 [nucleoplasm]
Authored
May, B  (2023-12-20)
Created
May, B  (2023-12-21)
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