ATF5 and HSF1 trimer activate expression of HSPA9 (mtHSP70)

Stable Identifier
R-HSA-9856627
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, mitochondrial matrix
ReviewStatus
3/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
ATF5 and HSF1 trimer activate expression of HSPA9 (mtHSP70)
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
During the mitochondrial response to unfolded protein (mtUPR), a reduction of mitochondrial protein import causes ATF5 to accumulate in the nucleus and activate expression of the mitochondrial chaperone HSPA9 (mtHSP70) (Fiorese et al. 2016). Trimeric Heat shock factor protein 1 (HSF1) phosphorylated on serine-326 is also required for expression of HSPA9 during the mtUPR (Sutandy et al. 2023, inferred from mouse homologs in Katiyar et al. 2020).
Literature References
PubMed ID Title Journal Year
37286597 A cytosolic surveillance mechanism activates the mitochondrial UPR

Tascher, G, Gößner, I, Münch, C, Sutandy, FXR

Nature 2023
27426517 The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR

Rosin, N, Haynes, CM, Schulz, AM, Fiorese, CJ, Pellegrino, MW, Lin, YF

Curr Biol 2016
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
ATF5:HSF1 trimer:HSPA9 gene [nucleoplasm] (Homo sapiens)
Active Unit
p-S326-hC36,103-HSF1 [nucleoplasm]
ATF5 [nucleoplasm]
Authored
May, B  (2023-12-19)
Created
May, B  (2023-12-20)
Cite Us!