p-S167-ESR1 activates expression of HTRA2 (OMI)

Stable Identifier
R-HSA-9856620
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, mitochondrial intermembrane space
ReviewStatus
3/5
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p-S167-ESR1 activates expression of HTRA2 (OMI)
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In response to unfolded protein in the mitochondrial matrix, AKT1 (PKB1) is phosphorylated by an unknown mechanism (Papa and Germain 2011) and then phosphorylates the estrogen receptor ESR1 (Campbell et al. 2001, Papa and Germain 2011), which transits to the nucleus and activates expression of HTRA2 (OMI), a serine protease involved in mitochondrial protein degradation (Papa and Germain 2011) independently of estrogen (Campbell et al. 2001).
Literature References
PubMed ID Title Journal Year
21486948 Estrogen receptor mediates a distinct mitochondrial unfolded protein response

Papa, L, Germain, D

J Cell Sci 2011
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Output
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This event is regulated
Positively by
Regulator
p-S167-ESR1 dimer [nucleoplasm] (Homo sapiens)
Authored
May, B  (2023-12-19)
Created
May, B  (2023-12-20)
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