Reactome | mito-STARD7 transports Q10 to outer mitochondrial membrane

mito-STARD7 transports Q10 to outer mitochondrial membrane

Stable Identifier

R-HSA-9856502

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial inner membrane, mitochondrial outer membrane

ReviewStatus

5/5

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mito-STARD7 transports Q10 to outer mitochondrial membrane

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Mitochondrial STARD7 is a lipid carrier that is required for transport of Q10H2 between inner and outer mitochondrial membranes (Deshwal et al., 2023; reviewed in Guile et al., 2023). In yeast, Cqd1 and Cqd2, two proteins containing atypical kinase/ATPase domains similar to those found in COQ8, regulate the cellular distribution of CoQ (Kemmerer et al., 2021).

Literature References

PubMed ID	Title	Journal	Year
36658222	Mitochondria regulate intracellular coenzyme Q transport and ferroptotic resistance via STARD7 Lemke, K, Tatsuta, T, Deshwal, S, Cors, E, Bartsch, T, Onishi, M, Nolte, H, Langer, T, Giavalisco, P, Ried, K	Nat Cell Biol	2023
34362905	UbiB proteins regulate cellular CoQ distribution in Saccharomyces cerevisiae Hutchins, PD, Pagliarini, DJ, Kemmerer, ZA, Schmitz, JM, Paulson, BR, Robinson, KP, Jochem, A, Manicki, M, Coon, JJ	Nat Commun	2021
37507930	New Insights on the Uptake and Trafficking of Coenzyme Q Guile, MD, Jain, A, Clarke, CF, Anderson, KA	Antioxidants (Basel)	2023