MITF-M-dependent GPR143 expression

Stable Identifier
R-HSA-9856053
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
melanosome membrane, nucleoplasm
ReviewStatus
5/5
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MITF-M-dependent GPR143 expression
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GPR143 encodes a GPCR that, with MLANA, plays a role in the maturation and localization of PMEL. In this capacity, GPR143 contributes to the melanosome maturation and organization (Cortese et al, 2005; Schaiffino and Tacchetti, 2005; Vetrini et al, 2004; Palmisano et al, 2008; Giordano et al, 2009; reviewed in Cheli et al, 2010). Regulation of GPR143 is controlled in part by the binding of MITF-M to an E-box element in the proximal promoter (Vetrini et al, 2004; Strub et al, 2011).
Literature References
PubMed ID Title Journal Year
15254223 The microphthalmia transcription factor (Mitf) controls expression of the ocular albinism type 1 gene: link between melanin synthesis and melanosome biogenesis

Vetrini, F, Ballabio, A, Fisher, DE, Marigo, V, Angeletti, B, Du, J, Auricchio, A

Mol Cell Biol 2004
19717472 The ocular albinism type 1 (OA1) G-protein-coupled receptor functions with MART-1 at early stages of melanogenesis to control melanosome identity and composition

Bonetti, C, Giordano, F, Surace, EM, Raposo, G, Marigo, V

Hum Mol Genet 2009
16029416 The ocular albinism type 1 (OA1) protein and the evidence for an intracellular signal transduction system involved in melanosome biogenesis

Schiaffino, MV, Tacchetti, C

Pigment Cell Res. 2005
21258399 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma

Ye, T, Cormont, M, Keime, C, Kobi, D, Davidson, I, Le Gras, S, Giuliano, S, Bonet, C, Bertolotto, C, Ballotti, R, Strub, T

Oncogene 2011
19995375 Fifteen-year quest for microphthalmia-associated transcription factor target genes

Bertolotto, C, Cheli, Y, Ohanna, M, Ballotti, R

Pigment Cell Melanoma Res 2010
16303920 The ocular albinism type 1 (OA1) gene controls melanosome maturation and size

Giordano, F, Surace, EM, Cortese, K, Ballabio, A, Tacchetti, C, Venturi, C, Marigo, V

Invest Ophthalmol Vis Sci 2005
18697795 The ocular albinism type 1 protein, an intracellular G protein-coupled receptor, regulates melanosome transport in pigment cells

Bennett, DC, Piccirillo, R, Surace, EM, Sviderskaya, EV, Ballabio, A, Bagnato, P, Innamorati, G, Tacchetti, C, Marigo, V, Schiaffino, MV, Venturi, C, Altimare, D, Palmisano, I, Incerti, B, Rotondo, G, Coppola, M, Palmigiano, A

Hum Mol Genet 2008
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
MITF-M dimer:GPR143 gene [nucleoplasm] (Homo sapiens)
Active Unit
MITF-M dimer [nucleoplasm]
Authored
Rothfels, K  (2023-12-21)
Reviewed
de la Serna, IL  (2024-05-21)
Arnheiter, H  (2024-02-26)
Steingrímsson, E  (2024-11-05)
Vu, HN  (2024-11-05)
Created
Rothfels, K  (2023-12-09)
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