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CALR [lumenal side of endoplasmic reticulum membrane]
Stable Identifier
R-HSA-985502
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
lumenal side of endoplasmic reticulum membrane
Synonyms
calreticulin
Locations in the PathwayBrowser for interactor UniProt:Q96EF9 ZHX1R
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Homo sapiens)
Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex (Homo sapiens)
CALR [lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
Formation of peptide loading complex (PLC) (Homo sapiens)
CALR [lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
Antigen processing-Cross presentation (Homo sapiens)
ER-Phagosome pathway (Homo sapiens)
Transport of SEC22B, TAP and PLC from ER to ERGIC (Homo sapiens)
CALR [lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P27797 CALR
Gene Names
CALR, CRTC
Chain
signal peptide:1-17, chain:18-417
Reference Genes
BioGPS Gene:811 CALR
COSMIC (genes):CALR CALR
CTD Gene:811 CALR
dbSNP Gene:811 CALR
ENSEMBL:ENSG00000179218 CALR
ENSEMBL_homo_sapiens_GENE:ENSG00000179218.15 CALR
HGNC:1455 CALR
KEGG Gene (Homo sapiens):811 CALR
Monarch:811 CALR
NCBI Gene:811 CALR
OMIM:109091 CALR
Reference Transcript
RefSeq:NM_004343.3 CALR
Other Identifiers
11715374_a_at
11715375_x_at
16858774
1752_at
200935_PM_at
200935_at
212953_PM_x_at
212953_x_at
214315_PM_x_at
214315_x_at
32543_at
3822050
3822051
3822053
3822054
3822055
3822056
3822057
3822058
3822059
3822060
3822065
3822066
3822067
3822068
3822069
3822070
3822071
3822072
3822073
8026106
811
A_14_P107778
A_23_P67288
A_33_P3292854
GE79860
GO:0000122
GO:0001669
GO:0001849
GO:0002376
GO:0002502
GO:0003677
GO:0003723
GO:0003729
GO:0005049
GO:0005178
GO:0005506
GO:0005509
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005635
GO:0005737
GO:0005764
GO:0005773
GO:0005783
GO:0005788
GO:0005789
GO:0005790
GO:0005829
GO:0005840
GO:0005886
GO:0005925
GO:0006351
GO:0006355
GO:0006457
GO:0006611
GO:0006874
GO:0006886
GO:0006913
GO:0007010
GO:0007155
GO:0007283
GO:0008270
GO:0008284
GO:0009410
GO:0009897
GO:0009986
GO:0010033
GO:0010595
GO:0010628
GO:0012501
GO:0012505
GO:0016020
GO:0016192
GO:0016529
GO:0017148
GO:0022414
GO:0022417
GO:0023052
GO:0030154
GO:0030163
GO:0030246
GO:0030312
GO:0030433
GO:0030670
GO:0030866
GO:0031012
GO:0031410
GO:0031625
GO:0032355
GO:0032991
GO:0033018
GO:0033116
GO:0033144
GO:0033574
GO:0034504
GO:0034975
GO:0040020
GO:0042277
GO:0042562
GO:0042824
GO:0042921
GO:0042981
GO:0043226
GO:0043231
GO:0044183
GO:0044194
GO:0044322
GO:0045665
GO:0045787
GO:0045892
GO:0046872
GO:0048387
GO:0048471
GO:0048856
GO:0048870
GO:0050681
GO:0050766
GO:0050821
GO:0051082
GO:0051087
GO:0051208
GO:0051604
GO:0055007
GO:0055065
GO:0060473
GO:0062023
GO:0065003
GO:0070062
GO:0071257
GO:0071285
GO:0071310
GO:0071682
GO:0090398
GO:0098553
GO:0098586
GO:0140013
GO:0140104
GO:0140313
GO:1900026
GO:1901164
GO:1901224
GO:1903416
GO:2000510
HMNXSV003044478
Hs.16488.2.A1_3p_x_at
Hs.16488.3.A1_3p_x_at
ILMN_1736256
M84739_at
PH_hs_0017137
TC19000232.hg
g5921996_3p_a_at
Participates
as an input of
Transport of SEC22B, TAP and PLC from ER to ERGIC (Homo sapiens)
Formation of peptide loading complex (PLC) (Homo sapiens)
as an output of
Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex (Homo sapiens)
as a component of
MHC:B2M peptide loading complex [endoplasmic reticulum membrane] (Homo sapiens)
Other forms of this molecule
CALR [extracellular region]
CALR [endocytic vesicle lumen]
CALR [endoplasmic reticulum lumen]
CALR [endoplasmic reticulum-Golgi intermediate compartment membrane]
CALR [phagocytic vesicle membrane]
Inferred To
calr [lumenal side of endoplasmic reticulum membrane]
(Xenopus tropicalis)
CALR [lumenal side of endoplasmic reticulum membrane]
(Bos taurus)
CALR [lumenal side of endoplasmic reticulum membrane]
(Caenorhabditis elegans)
CALR [lumenal side of endoplasmic reticulum membrane]
(Canis familiaris)
CALR [lumenal side of endoplasmic reticulum membrane]
(Dictyostelium discoideum)
CALR [lumenal side of endoplasmic reticulum membrane]
(Drosophila melanogaster)
CALR [lumenal side of endoplasmic reticulum membrane]
(Gallus gallus)
CALR [lumenal side of endoplasmic reticulum membrane]
(Mus musculus)
CALR [lumenal side of endoplasmic reticulum membrane]
(Rattus norvegicus)
CALR [lumenal side of endoplasmic reticulum membrane]
(Sus scrofa)
calr3a [lumenal side of endoplasmic reticulum membrane]
(Danio rerio)
Cross References
RefSeq
NP_004334.1
OpenTargets
ENSG00000179218
GeneCards
P27797
HPA
ENSG00000179218-CALR
Ensembl
ENSG00000179218
,
ENSP00000466037
,
ENST00000316448
,
ENSP00000320866
,
ENST00000586967
PRO
P27797
Pharos - Targets
P27797
Orphanet
22642
HMDB Protein
HMDBP07533
PDB
5LK5
,
3POS
,
3POW
,
8TZO
,
3DOW
,
5V90
,
7QPD
,
8TZR
,
6ENY
,
2CLR
Interactors (93)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.737
5
UniProt:O95166 GABARAP
3
GABARAP [autophagosome membrane]
(R-HSA-5683634)
GABARAP(1-117) [cytosol]
(R-HSA-5682696)
GABARAP [cytosol]
(R-HSA-975521)
0.71
4
UniProt:P48039 MTNR1A
1
MTNR1A [plasma membrane]
(R-HSA-419316)
0.659
3
UniProt:Q12824 SMARCB1
1
SMARCB1 [nucleoplasm]
(R-HSA-389261)
0.594
5
UniProt:P30101 PDIA3
3
PDIA3 [phagocytic vesicle]
(R-HSA-1236870)
PDIA3 [recycling endosome membrane]
(R-HSA-8863849)
PDIA3 [endoplasmic reticulum lumen]
(R-HSA-901028)
0.589
2
UniProt:Q96EF9 ZHX1R
0.556
3
UniProt:P09471 GNAO1
1
GNAO1 [plasma membrane]
(R-HSA-2997536)
0.556
3
UniProt:Q68CL5-3 TPGS2
0.556
3
UniProt:O75175 CNOT3
1
CNOT3 [cytosol]
(R-HSA-429872)
0.556
3
UniProt:Q9NX07 TSAP1
0.556
3
UniProt:Q7Z698 SPRED2
2
SPRED2 [cytosol]
(R-HSA-5654211)
SPRED2 [plasma membrane]
(R-HSA-5658229)
0.556
3
IntAct:EBI-25833913 CCSB
0.556
3
UniProt:Q3SY56 SP6
0.556
3
IntAct:EBI-25831691 CCSB
0.556
3
UniProt:Q96E17 RAB3C
2
GGC-RAB3C [cytosol]
(R-HSA-8874012)
RAB3C [cytosol]
(R-HSA-8873684)
0.556
3
UniProt:Q9NVM1 EVA1B
0.556
3
UniProt:O94983-5 CAMTA2
0.556
3
UniProt:Q9HC98-4 NEK6
0.556
3
UniProt:Q10981 FUT2
1
FUT2 [Golgi membrane]
(R-HSA-2980904)
0.556
3
UniProt:P36382 GJA5
1
GJA5 [endoplasmic reticulum membrane]
(R-HSA-190648)
0.556
3
UniProt:Q7Z780 Q7Z780
0.556
3
UniProt:Q96GK7 FAH2A
0.556
3
UniProt:Q8TAB5 CA216
0.556
3
UniProt:Q02978 SLC25A11
1
SLC25A11 [mitochondrial inner membrane]
(R-HSA-198451)
0.556
3
UniProt:P49184 DNASE1L1
2
DNASE1L1 [extracellular region]
(R-HSA-6806320)
DNASE1L1 [specific granule lumen]
(R-HSA-6799554)
0.556
3
UniProt:Q9H2S6-2 TNMD
0.556
3
UniProt:Q96L03 SPT17
0.556
3
UniProt:F6Y2X3 F6Y2X3
0.556
3
UniProt:Q96I25 RBM17
1
RBM17 [nucleoplasm]
(R-HSA-8865891)
0.556
3
UniProt:A2RUH7 MBPHL
0.556
3
UniProt:Q9BT49 THAP7
0.556
3
UniProt:Q8N1W1-4 ARHGEF28
0.556
3
UniProt:Q9Y617 PSAT1
1
PXLP-K200-PSAT1 [cytosol]
(R-HSA-977330)
0.556
3
UniProt:Q9BQ29 Q9BQ29
0.556
3
UniProt:O15499 GSC2
0.556
3
UniProt:Q8TB02 Q8TB02
0.556
3
UniProt:P43356 MAGA2
0.556
3
UniProt:Q8N2W9 PIAS4
2
PIAS4 [nucleoplasm]
(R-HSA-2993789)
monoSUMO1-K35-PIAS4 [nucleoplasm]
(R-HSA-3968415)
0.556
3
UniProt:Q96JJ7-2 Q96JJ72
0.556
3
UniProt:P14060 HSD3B1
1
HSD3B1 [endoplasmic reticulum membrane]
(R-HSA-192072)
0.556
3
UniProt:P79483 HLA-DRB3
9
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [lumenal side of endoplasmic reticulum membrane]
(R-HSA-2130513)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [ER to Golgi transport vesicle membrane]
(R-HSA-2130432)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [Golgi membrane]
(R-HSA-2214381)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [trans-Golgi network membrane]
(R-HSA-2130452)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [transport vesicle membrane]
(R-HSA-2130559)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130515)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [endocytic vesicle membrane]
(R-HSA-2130377)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [lysosomal membrane]
(R-HSA-2130676)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [plasma membrane]
(R-HSA-197577)
0.556
3
UniProt:Q6P4D5-2 PABIR3
0.556
3
UniProt:Q6P5S2 LEG1H
0.556
3
UniProt:O75317 USP12
1
USP12 [nucleoplasm]
(R-HSA-5696907)
0.556
3
IntAct:EBI-25834143 CCSB
0.556
3
IntAct:EBI-25833532 RZPDO839F06154
0.556
3
UniProt:O75874 IDH1
10
IDH1 R132H mutant [cytosol]
(R-HSA-880015)
IDH1 R132L mutant [cytosol]
(R-HSA-880000)
IDH1 R132S mutant [cytosol]
(R-HSA-880048)
IDH1 R132C mutant [cytosol]
(R-HSA-880031)
IDH1 [secretory granule lumen]
(R-HSA-6800980)
IDH1 [ficolin-1-rich granule lumen]
(R-HSA-6800977)
IDH1 [extracellular region]
(R-HSA-6806433)
IDH1 [tertiary granule lumen]
(R-HSA-6800163)
IDH1 [cytosol]
(R-HSA-389549)
IDH1 [peroxisomal matrix]
(R-HSA-389546)
0.556
3
UniProt:Q13636 RAB31
5
GGC-RAB31 [early endosome membrane]
(R-HSA-8877278)
GGC-RAB31 [cytosol]
(R-HSA-8873974)
RAB31 [cytosol]
(R-HSA-8873690)
RAB31 [plasma membrane]
(R-HSA-6804813)
RAB31 [secretory granule membrane]
(R-HSA-6804797)
0.556
3
UniProt:Q8NBT0 POC1A
0.556
3
UniProt:P52756 RBM5
1
RBM5 [nucleoplasm]
(R-HSA-72049)
0.556
3
UniProt:Q96EQ0 SGTB
0.556
3
UniProt:Q96EY8 MMAB
4
MMAB E193K [mitochondrial matrix]
(R-HSA-3322150)
MMAB R191W [mitochondrial matrix]
(R-HSA-3322112)
MMAB R186W [mitochondrial matrix]
(R-HSA-3322128)
MMAB [mitochondrial matrix]
(R-HSA-2980970)
0.556
3
UniProt:P49746 THBS3
1
THBS3 [extracellular region]
(R-HSA-66522)
0.556
3
UniProt:A0JP07 A0JP07
0.556
3
UniProt:P48775 TDO2
1
TDO2 [cytosol]
(R-HSA-71184)
0.556
3
UniProt:P43686 PSMC4
2
PSMC4 [nucleoplasm]
(R-HSA-174315)
PSMC4 [cytosol]
(R-HSA-68777)
0.556
3
UniProt:O00214-2 LGALS8
0.556
3
UniProt:Q9ULR0 ISY1
1
ISY1 [nucleoplasm]
(R-HSA-6781963)
0.556
3
UniProt:Q9Y3Y4 PYGO1
1
PYGO1 [nucleoplasm]
(R-HSA-201705)
0.556
3
UniProt:Q96QH2 PRAM
0.556
3
UniProt:O14829 PPEF1
1
PPEF1 [cytosol]
(R-HSA-2632517)
0.556
3
UniProt:Q99944 EGFL8
0.556
3
UniProt:Q8NCF5-2 NFATC2IP
0.556
3
UniProt:P50749 RASF2
0.556
3
UniProt:Q8NCR3 MFI
0.556
3
UniProt:P09382 LGALS1
2
p-LGALS1 [endoplasmic reticulum lumen]
(R-HSA-8957003)
LGALS1 [endoplasmic reticulum lumen]
(R-HSA-8956711)
0.556
3
IntAct:EBI-25833762 CCSB
0.556
3
UniProt:Q96P20 NLRP3
2
K63polyUb-NLRP3 [cytosol]
(R-HSA-6783288)
NLRP3 [cytosol]
(R-HSA-561189)
0.556
3
IntAct:EBI-25833683 CCSB
0.556
3
UniProt:Q8IY82 DRC7
0.556
3
UniProt:Q9NPC7 MYNN
0.556
3
UniProt:Q8N323 NXPE1
0.556
3
UniProt:Q6UXH1-2 CRELD2
0.556
3
UniProt:Q7Z6Z7-2 HUWE1
0.556
3
UniProt:P07437 TUBB
3
TUBB [cytosol]
(R-HSA-9020816)
TUBB [azurophil granule lumen]
(R-HSA-6799370)
TUBB [extracellular region]
(R-HSA-380317)
0.556
3
UniProt:Q7Z434 MAVS
2
MAVS [mitochondrial outer membrane]
(R-HSA-913730)
K48polyUb-MAVS [mitochondrial outer membrane]
(R-HSA-983463)
0.556
3
UniProt:Q9ULW0 TPX2
2
TPX2 [cytosol]
(R-HSA-8853407)
TPX2 [nucleoplasm]
(R-HSA-2564700)
0.556
3
UniProt:Q53T94 TAF1B
2
TAF1B [nucleoplasm]
(R-HSA-73691)
Ac-TAF1B [nucleoplasm]
(R-HSA-5138530)
0.556
3
UniProt:P61224 RAP1B
2
RAP1B [azurophil granule membrane]
(R-HSA-6804972)
RAP1B [plasma membrane]
(R-HSA-377590)
0.556
3
UniProt:Q13200 PSMD2
5
PSMD2 [secretory granule lumen]
(R-HSA-6800919)
PSMD2 [extracellular region]
(R-HSA-6806479)
PSMD2 [ficolin-1-rich granule lumen]
(R-HSA-6800435)
PSMD2 [nucleoplasm]
(R-HSA-174311)
PSMD2 [cytosol]
(R-HSA-68796)
0.556
3
UniProt:P16422 EPCAM
1
EPCAM [plasma membrane]
(R-HSA-375068)
0.556
3
UniProt:P26715 KLRC1
1
KLRC1 [plasma membrane]
(R-HSA-3006545)
0.556
3
UniProt:P11226 MBL2
1
MBL2 [extracellular region]
(R-HSA-166674)
0.544
6
UniProt:P05111 INHA
1
INHA [extracellular region]
(R-HSA-1449702)
0.527
2
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.527
4
UniProt:O00755 WNT7A
9
WNT7A [extracellular region]
(R-HSA-517404)
N4GlycoAsn-PalmS WNT7A [extracellular exosome]
(R-HSA-3781951)
N4GlycoAsn-PalmS WNT7A [endocytic vesicle membrane]
(R-HSA-3781961)
WNT7A [endoplasmic reticulum lumen]
(R-HSA-3238312)
N4GlycoAsn-WNT7A [endoplasmic reticulum lumen]
(R-HSA-3238249)
N4GlycoAsn-PalmS WNT7A [endoplasmic reticulum lumen]
(R-HSA-3238354)
N4GlycoAsn-PalmS WNT7A [Golgi lumen]
(R-HSA-3247778)
N4GlycoAsn-PalmS WNT7A [extracellular region]
(R-HSA-3247774)
N4GlycoAsn-PalmS WNT7A [plasma membrane]
(R-HSA-3247833)
0.527
2
UniProt:Q6FHJ7 SFRP4
0.527
2
UniProt:P12644 BMP4
4
BMP4 [extracellular region]
(R-HSA-8858573)
BMP4 [endoplasmic reticulum lumen]
(R-HSA-8956775)
p-BMP4 [endoplasmic reticulum lumen]
(R-HSA-8956944)
BMP4(20-408) [extracellular region]
(R-HSA-2396280)
0.527
2
UniProt:P04792 HSBP1
3
HSPB1 [cytosol]
(R-HSA-450563)
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.508
2
UniProt:Q96GX1 TCTN2
1
TCTN2 [ciliary membrane]
(R-HSA-5626661)
0.508
2
UniProt:Q03518 TAP1
3
TAP1 [phagocytic vesicle membrane]
(R-HSA-1236845)
TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-8863953)
TAP1 [endoplasmic reticulum membrane]
(R-HSA-947474)
0.499
2
UniProt:P29991-PRO_0000037946
0.488
2
UniProt:P04578 env
7
Surface protein gp120 (P04578) [cytosol]
(R-HIV-189269)
Transmembrane protein gp41 (P04578) [cytosol]
(R-HIV-189359)
Glycosylated Envelope glycoprotein gp160 [Golgi membrane]
(R-HIV-3149443)
Envelope glycoprotein gp160 [endoplasmic reticulum membrane]
(R-HIV-189343)
Transmembrane protein gp41 [viral envelope]
(R-HIV-171195)
ENV [viral envelope]
(R-HIV-173439)
Surface protein gp120 [viral envelope]
(R-HIV-171211)
0.462
4
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