Reactome | SDHAF1 [mitochondrial matrix]

SDHAF1 [mitochondrial matrix]

Stable Identifier

R-HSA-9854988

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:A6NFY7 SDHAF1

Gene Names

SDHAF1, LYRM8

Chain

chain:1-115

Reference Genes

BioGPS Gene:644096 SDHAF1

COSMIC (genes):SDHAF1 SDHAF1

CTD Gene:644096 SDHAF1

dbSNP Gene:644096 SDHAF1

ENSEMBL:ENSG00000205138 SDHAF1

HGNC:33867 SDHAF1

KEGG:hsa:644096 SDHAF1

Monarch:644096 SDHAF1

NCBI Gene:644096 SDHAF1

OMIM:612848 SDHAF1

UCSC:A6NFY7 SDHAF1

Reference Transcript

RefSeq:NM_001042631.2 SDHAF1

Other Identifiers

11717712_at

16861314

221855_3p_at

221855_PM_at

221855_at

3831036

3831037

3831038

3831039

44669_PM_at

44669_at

4871517C_3p_s_at

644096

A_32_P23010

GO:0005515

GO:0005654

GO:0005739

GO:0005759

GO:0034553

GO:0043226

GO:0065003

HMNXSV003007925

Hs.31754.0.A1_3p_at

Hs.31754.0.A1_3p_s_at

ILMN_2070355

TC19000491.hg

Participates

as an output of

SDHA:SDHB binds to SDHC:SDHD (Homo sapiens)

as a component of

SDHB:2Fe-2S:3Fe-4S:4Fe-4S:SDHAF1:SDHAF3 [mitochondrial matrix] (Homo sapiens)

as an input of

Transfer of Fe-S clusters to SDHB (Homo sapiens)

Inferred To

SDHAF1 [mitochondrial matrix] (Bos taurus)

SDHAF1 [mitochondrial matrix] (Canis familiaris)

SDHAF1 [mitochondrial matrix] (Sus scrofa)

Ghost homologue of SDHAF1 [mitochondrial matrix] (Caenorhabditis elegans)

Ghost homologue of SDHAF1 [mitochondrial matrix] (Danio rerio)

Ghost homologue of SDHAF1 [mitochondrial matrix] (Dictyostelium discoideum)

Ghost homologue of SDHAF1 [mitochondrial matrix] (Drosophila melanogaster)

Ghost homologue of SDHAF1 [mitochondrial matrix] (Gallus gallus)

Ghost homologue of SDHAF1 [mitochondrial matrix] (Rattus norvegicus)

Ghost homologue of SDHAF1 [mitochondrial matrix] (Saccharomyces cerevisiae)

Ghost homologue of SDHAF1 [mitochondrial matrix] (Schizosaccharomyces pombe)

Sdhaf1 [mitochondrial matrix] (Mus musculus)

sdhaf1 [mitochondrial matrix] (Xenopus tropicalis)

Cross References

RefSeq

NP_001036096.1

ENSEMBL

ENST00000378887, ENSP00000368165

OpenTargets

ENSG00000205138

HPA

ENSG00000205138-SDHAF1

PRO

A6NFY7

Pharos - Targets

A6NFY7

Orphanet

SDHAF1

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P21912 SDHB	2	SDHB [mitochondrial inner membrane] (R-HSA-70985) SDHB [mitochondrial matrix] (R-HSA-9854983)	0.793	13
UniProt:Q8IWL3 HSCB	5	HSCB [mitochondrial matrix] (R-HSA-1299438) HSCB(1-30) [mitochondrial matrix] (R-HSA-8986120) HSCB(1-235) [mitochondrial inner membrane] (R-HSA-1299443) HSCB [mitochondrial inner membrane] (R-HSA-1299447) HSCB(1-235) [mitochondrial intermembrane space] (R-HSA-1299456)	0.748	5
UniProt:Q7Z3Y8 KRT27	1	KRT27 [cytosol] (R-HSA-6809587)	0.556	3
UniProt:Q9UHD4 CIDEB			0.556	3
IntAct:EBI-16435328 CCSB ORF ID			0.556	3
UniProt:P38646 HSPA9	6	HSPA9(1-679) [cytosol] (R-HSA-1267964) HSPA9(1-679) [mitochondrial intermembrane space] (R-HSA-1267968) HSPA9 [mitochondrial inner membrane] (R-HSA-1252206) HSPA9 [mitochondrial matrix] (R-HSA-8878802) HSPA9 [nucleoplasm] (R-HSA-5252128) HSPA9 [cytosol] (R-HSA-5251993)	0.462	2
UniProt:Q9H1K1 ISCU	1	ISCU [cytosol] (R-HSA-9771680)	0.462	2

Cite Us!