Reactome | SDHAF4 binds to FAD-SDHA

SDHAF4 binds to FAD-SDHA

Stable Identifier

R-HSA-9854961

Type

Reaction [binding]

Species

Homo sapiens

Compartment

mitochondrial matrix

ReviewStatus

5/5

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Succinate dehydrogenase assembly factor 4 (SDHAF4) binds to flavinylated SDH complex subunit A (SDHA), stabilizing it before assembly into the SDH complex. The process has been shown in yeast and mice (Van Vranken et al., 2014; Wang et al., 2022).

Literature References

PubMed ID	Title	Journal	Year
35037426	Hepatic Suppression of Mitochondrial Complex II Assembly Drives Systemic Metabolic Benefits Liu, J, Yang, M, Long, J, Wang, X, Zhang, F, Wang, X, Zeng, M, Zheng, A, Cao, K, Cui, Y, Li, H, Shao, Y, Zou, X, Feng, Z, Xu, J, Lv, W	Adv Sci (Weinh)	2022
24954416	SDHAF4 promotes mitochondrial succinate dehydrogenase activity and prevents neurodegeneration Thummel, CS, Cox, JE, Rutter, J, Gygi, SP, Van Vranken, JG, Dephoure, N, Bricker, DK	Cell Metab	2014