MITF-M-dependent SIRT1 gene expression

Stable Identifier
R-HSA-9854916
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MITF-M-dependent SIRT1 gene expression
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MITF-M-dependent SIRT1 expression contributes to cellular proliferation and suppression of senescence in melanoma cells (Ohanna et al, 2014). SIRT1 contributes to metabolic reprogramming downstream of MITF-M through regulation of acetylation of targets such as PPARGC1A and CBP/EP300 (Bosch-Segue and Vaquero, 2011; Canto et al, 2009; Bouras et al, 2005; reviewed in Goding and Arnheiter, 2019; Falletta et al, 2022).
Literature References
PubMed ID Title Journal Year
35912100 Connecting Metabolic Rewiring With Phenotype Switching in Melanoma

Vivas-García, Y, Goding, CR, Falletta, P

Front Cell Dev Biol 2022
24742694 SIRT1 promotes proliferation and inhibits the senescence-like phenotype in human melanoma cells

Bertolotto, C, Bille, K, Davidson, I, Bonet, C, Allegra, M, Ohanna, M, Lacour, JP, Ballotti, R, Bahadoran, P

Oncotarget 2014
31123060 MITF-the first 25 years

Arnheiter, H, Goding, CR

Genes Dev 2019
21941620 The dual role of sirtuins in cancer

Vaquero, A, Bosch-Presegué, L

Genes Cancer 2011
15632193 SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1

Sauve, AA, Gu, W, Perkins, ND, Hay, RT, Pestell, RG, Wang, F, Quong, AA, Bouras, T, Fu, M

J Biol Chem 2005
19262508 AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

Cantó, C, Gerhart-Hines, Z, Milne, JC, Elliott, PJ, Lagouge, M, Noriega, L, Feige, JN, Auwerx, J, Puigserver, P

Nature 2009
Participants
Input
Output
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as an event of
This event is regulated
Positively by
Regulator
MITF-M dimer:SIRT1 gene [nucleoplasm] (Homo sapiens)
Active Unit
MITF-M dimer [nucleoplasm]
Authored
Rothfels, K  (2023-12-21)
Reviewed
de la Serna, IL  (2024-05-21)
Arnheiter, H  (2024-02-26)
Steingrímsson, E  (2024-11-05)
Vu, HN  (2024-11-05)
Created
Rothfels, K  (2023-11-28)
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