MITF-M-dependent PPARGC1A gene expression

Stable Identifier
R-HSA-9854906
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MITF-M-dependent PPARGC1A gene expression
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MITF-M activates the expression of PPARGC1A by binding to E-box elements in its promoter (Haq et al, 2013; Vazquez et al 2013). PPARGC1A is a transcriptional co-activator that has roles in mitochondrial biogenesis and expression of genes involved in oxidative phosphorylation (Mootha et al, 2003; reviewed in Goding and Arnheiter, 2019). Upregulation of PPARGC1A consequently promotes a metabolic shift towards oxidative phosphorylation (Haq et al, 2013; Vazquez et al, 2013; reviewed in Falletta et al, 2022). PPARGC1A has also been identified as a transcriptional activator of MITF-M in concert with SOX10, establishing a positive feedback loop (Shoag et al, 2013).
Literature References
PubMed ID Title Journal Year
35912100 Connecting Metabolic Rewiring With Phenotype Switching in Melanoma

Vivas-García, Y, Goding, CR, Falletta, P

Front Cell Dev Biol 2022
12808457 PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

Golub, TR, Patterson, N, Houstis, N, Spiegelman, B, Laurila, E, Daly, MJ, Eriksson, KF, Sihag, S, Altshuler, D, Tamayo, P, Mootha, VK, Groop, LC, Mesirov, JP, Subramanian, A, Ridderstrale, M, Carlsson, E, Lehar, J, Puigserver, P, Hirschhorn, JN, Lander, ES, Lindgren, CM

Nat Genet 2003
31123060 MITF-the first 25 years

Arnheiter, H, Goding, CR

Genes Dev 2019
23201126 PGC-1 coactivators regulate MITF and the tanning response

Han, J, Rowe, GC, Qureshi, AA, Cui, R, Fisher, DE, Shoag, J, Zhang, J, Farrel, C, Jiang, A, Lee, JE, Arany, Z, Haq, R, Amos, CI, Kupper, TS, Zhang, M, Liu, L, Wei, Q, Koulisis, N

Mol Cell 2013
23416000 PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress

Widlund, HR, Bhalla, K, Spiegelman, BM, Puigserver, P, Girnun, G, Clish, CB, Lim, JH, Pierce, K, Granter, SR, Chim, H, Vazquez, F

Cancer Cell 2013
23477830 Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF

Andreu-Perez, P, Nellore, A, Hurley, AD, Song, JS, Edelman, H, Kung, AL, Rowe, GC, Yokoyama, S, Fisher, DE, Arany, Z, Shoag, J, Wargo, JA, Widlund, HR, Frederick, DT, Haq, R

Cancer Cell 2013
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
MITF-M dimer:PPARGC1A gene [nucleoplasm] (Homo sapiens)
Active Unit
MITF-M [nucleoplasm]
Authored
Rothfels, K  (2023-11-10)
Reviewed
de la Serna, IL  (2024-05-21)
Arnheiter, H  (2024-02-26)
Steingrímsson, E  (2024-11-05)
Vu, HN  (2024-11-05)
Created
Rothfels, K  (2023-11-28)
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