CSKMT methylates Citrate Synthase

Stable Identifier
R-HSA-9854315
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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(Citrate-synthase)-lysyl-methyltransferase (CSKMT, METTL12) transfers three methyl groups from S-adenosylmethionine (SAM) to lysine-395 of citrate synthase (CS). The modification is evolutionarily conserved and attenuates the activity of CS by about 30% in vitro. The trimethylated form is predominant in most cell lines tested. Oxaloacetate and S-adenosylhomocysteine inhibit methyltransferase activity (Malecki et al., 2017; Rhein et al., 2017; reviewed in Qi et al., 2023).
Literature References
PubMed ID Title Journal Year
37533128 Methyltransferase-like proteins in cancer biology and potential therapeutic targeting

Qi, YN, Ling, ZQ, Li, P, Hong, LL, Liu, Z

J Hematol Oncol 2023
28391595 Human METTL12 is a mitochondrial methyltransferase that modifies citrate synthase

Fearnley, IM, Carroll, J, Walker, JE, Ding, S, Rhein, VF

FEBS Lett 2017
28887308 Uncovering human METTL12 as a mitochondrial methyltransferase that modulates citrate synthase activity through metabolite-sensitive lysine methylation

Jakobsson, ME, Falnes, PØ, Małecki, J, Rustan, AC, Moen, A, Ho, AYY

J Biol Chem 2017
Participants
Participates
Catalyst Activity

protein-lysine N-methyltransferase activity of CSKMT [mitochondrial matrix]

This event is regulated
Orthologous Events
Cross References
RHEA
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