GPAM gene expression is stimulated by PPARG2:RXRA:MLL4,(MLL3)-ASCOM complex

Stable Identifier
R-HSA-9854141
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, mitochondrial outer membrane
ReviewStatus
3/5
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GPAM gene expression is stimulated by PPARG2:RXRA:MLL4,(MLL3)-ASCOM complex
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Based on a mouse model of hepatic steatosis, expression of the GPAM gene, encoding Glycerol-3-phosphate acyltransferase that localizes to the mitochondrial outer membrane, is directly stimulated by PPARG2 and the KMT2D (MLL4) complex (Kim et al. 2016). Gpam gene expression is reduced in differentiating mouse brown preadipocytes expressing histone H3.3 K4M mutant or Kmt2c (Mll3) and Kmt2d (Mll4) with deleted SET domains (Jang et al. 2019: RNA seq, supplementary information).
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Output
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This event is regulated
Positively by
Regulator
Activated p-Y78,Y102-PPARG2:RXRA:GPAM gene:H3K4me1-nucleosomes:MLL4-ASCOM,(MLL3-ASCOM) [nucleoplasm] (Homo sapiens)
Inferred From
Gpam gene expression is stimulated by Pparg2:Rxra and Mll4,(Mll3) complex (Mus musculus)
Authored
Orlic-Milacic, M  (2023-11-22)
Created
Orlic-Milacic, M  (2023-11-22)
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