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Activated p-Y78,Y102-PPARG2:RXRA:ELOVL5 gene:H3K4me1-nucleosomes:MLL4-ASCOM,(MLL3-ASCOM) [nucleoplasm]
Stable Identifier
R-HSA-9854070
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Epigenetic regulation by WDR5-containing histone modifying complexes (Homo sapiens)
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes (Homo sapiens)
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes (Homo sapiens)
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis (Homo sapiens)
ELOVL5 gene expression is stimulated by PPARG2:RXRA:MLL4(MLL3)-ASCOM complex (Homo sapiens)
Activated p-Y78,Y102-PPARG2:RXRA:ELOVL5 gene:H3K4me1-nucleosomes:MLL4-ASCOM,(MLL3-ASCOM) [nucleoplasm] (Homo sapiens)
KMT2D,(KMT2C) complex monomethylates nucleosomes at PPARG:RXRA-bound enhancers (Homo sapiens)
Activated PPARG:RXRA:adipogenesis genes:H3K4me1-Nucleosomes:MLL4,(MLL3)-ASCOM [nucleoplasm] (Homo sapiens)
Activated p-Y78,Y102-PPARG2:RXRA:ELOVL5 gene:H3K4me1-nucleosomes:MLL4-ASCOM,(MLL3-ASCOM) [nucleoplasm] (Homo sapiens)
Participants
components
CREBBP,EP300 [nucleoplasm]
(Homo sapiens)
MLL4-ASCOM,(MLL3-ASCOM) [nucleoplasm]
(Homo sapiens)
NCOAs (PPARG,RXRA) [nucleoplasm]
(Homo sapiens)
p-Y78,Y102-PPARG2:RXRA:ELOVL5 gene:H3K4me1-nucleosomes [nucleoplasm]
(Homo sapiens)
PPARG natural ligands [nucleoplasm]
PPARGC1A, PPARGC1B [nucleoplasm]
(Homo sapiens)
RXRA natural ligands [nucleoplasm]
TRAP coactivator complex [nucleoplasm]
(Homo sapiens)
Participates
as a member of
Activated PPARG:RXRA:adipogenesis genes:H3K4me1-Nucleosomes:MLL4,(MLL3)-ASCOM [nucleoplasm] (Homo sapiens)
This entity regulates
Positively
ELOVL5 gene expression is stimulated by PPARG2:RXRA:MLL4(MLL3)-ASCOM complex
(Homo sapiens)
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