Reactome | SuccinyllipoH2-K110-DLST [mitochondrial matrix]

SuccinyllipoH2-K110-DLST [mitochondrial matrix]

Stable Identifier

R-HSA-9853502

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

alpha-ketoglutarate dehydrogenase E2, DLST, Dihydrolipoamide succinyltransferase

Locations in the PathwayBrowser for interactor UniProt:Q96EF9 ZHX1R

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External Reference Information

External Reference

UniProt:P36957 DLST

Gene Names

DLST, DLTS

Chain

transit peptide:1-67, chain:68-453

Reference Genes

BioGPS Gene:1743 DLST

COSMIC (genes):DLST DLST

CTD Gene:1743 DLST

dbSNP Gene:1743 DLST

ENSEMBL:ENSG00000119689 DLST

ENSEMBL_homo_sapiens_GENE:ENSG00000119689.15 DLST

HGNC:2911 DLST

KEGG Gene (Homo sapiens):1743 DLST

Monarch:1743 DLST

NCBI Gene:1743 DLST

OMIM:126063 DLST

UCSC:P36957 DLST

Reference Transcript

RefSeq:NM_001933.4 DLST

Other Identifiers

11720929_a_at

11720930_s_at

11720931_x_at

11720932_s_at

11748080_a_at

11751226_x_at

16786524

1743

215210_PM_s_at

215210_s_at

2418675

2418678

2418682

33257_at

33258_g_at

3544351

3544352

3544353

3544354

3544355

3544356

3544358

3544360

3544363

3544364

3544365

3544367

3544369

3544370

3544372

3544373

3544374

3544375

3544376

3544377

3544378

3544379

3544380

3544381

45545_at

7975747

A_14_P109426

A_24_P13572

D26535_s_at

GE61495

GO:0003824

GO:0004149

GO:0005515

GO:0005634

GO:0005654

GO:0005739

GO:0005759

GO:0005829

GO:0006091

GO:0006099

GO:0006103

GO:0006104

GO:0006520

GO:0006790

GO:0016020

GO:0016740

GO:0016746

GO:0033512

GO:0036211

GO:0043226

GO:0045252

GO:0055086

GO:0106077

GO:0140096

GO:1901135

GO:1990204

HMNXSV003018081

HMNXSV003048834

Hs.296348.0.S1_3p_s_at

ILMN_1773228

PH_hs_0029663

PH_hs_0032549

TC14000465.hg

TC14001772.hg

Participates

as an input of

DLST transfers succinyl to CoA (Homo sapiens)

as an output of

OGDH dimer decarboxylates 2-OG (Homo sapiens)

Other forms of this molecule

Lipo-K110-DLST [mitochondrial matrix]

LipoH2-K110-DLST [mitochondrial matrix]

GlutaryllipoH2-K110-DLST [mitochondrial matrix]

DLST [mitochondrial matrix]

Inferred To

KGD2 [mitochondrial matrix] (Saccharomyces cerevisiae)

odhB [mitochondrial matrix] (Dictyostelium discoideum)

dlst-1 [mitochondrial matrix] (Caenorhabditis elegans)

DLST [mitochondrial matrix] (Bos taurus)

DLST [mitochondrial matrix] (Canis familiaris)

DLST [mitochondrial matrix] (Gallus gallus)

DLST [mitochondrial matrix] (Sus scrofa)

Dlst [mitochondrial matrix] (Drosophila melanogaster)

Dlst [mitochondrial matrix] (Mus musculus)

Dlst [mitochondrial matrix] (Rattus norvegicus)

SuccinyllipoH2-K110-DLST [mitochondrial matrix] (Plasmodium falciparum)

kgd2 [mitochondrial matrix] (Schizosaccharomyces pombe)

dlst [mitochondrial matrix] (Danio rerio)

dlst [mitochondrial matrix] (Xenopus tropicalis)

Modified Residues

Name

N6-lipoyl-L-lysine ((R)-N6-(S8-succinyldihydrolipoyl)-L-lysine residue) at 110

Coordinate

110

Modification

(R)-N6-(S8-succinyldihydrolipoyl)-L-lysine residue

PsiMod Name

N6-lipoyl-L-lysine [MOD:00127]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-lipoyl-L-lysine.

Cross References

RefSeq

NP_001924.2

OpenTargets

ENSG00000119689

IntEnz

2.3.1.61

HPA

ENSG00000119689-DLST

GeneCards

P36957

Ensembl

ENSG00000119689, ENSP00000335304, ENST00000334220

PRO

P36957

Pharos - Targets

P36957

PDB

6H05

HMDB Protein

HMDBP00939

Interactors (81)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P43686 PSMC4	2	PSMC4 [nucleoplasm] (R-HSA-174315) PSMC4 [cytosol] (R-HSA-68777)	0.666	5
UniProt:Q96EF9 ZHX1R			0.556	3
UniProt:Q68CL5-3 TPGS2			0.556	3
UniProt:P09471 GNAO1	1	GNAO1 [plasma membrane] (R-HSA-2997536)	0.556	3
UniProt:O75175 CNOT3	1	CNOT3 [cytosol] (R-HSA-429872)	0.556	3
UniProt:Q9NX07 TSAP1			0.556	3
UniProt:Q7Z698 SPRED2	2	SPRED2 [cytosol] (R-HSA-5654211) SPRED2 [plasma membrane] (R-HSA-5658229)	0.556	3
IntAct:EBI-25833913 CCSB			0.556	3
UniProt:Q3SY56 SP6			0.556	3
IntAct:EBI-25831691 CCSB			0.556	3
UniProt:Q96E17 RAB3C	2	GGC-RAB3C [cytosol] (R-HSA-8874012) RAB3C [cytosol] (R-HSA-8873684)	0.556	3
UniProt:Q9NVM1 EVA1B			0.556	3
UniProt:O94983-5 CAMTA2			0.556	3
UniProt:Q9HC98-4 NEK6			0.556	3
UniProt:P36382 GJA5	1	GJA5 [endoplasmic reticulum membrane] (R-HSA-190648)	0.556	3
UniProt:Q7Z780 Q7Z780			0.556	3
UniProt:Q96GK7 FAH2A			0.556	3
UniProt:Q8TAB5 CA216			0.556	3
UniProt:Q02978 SLC25A11	1	SLC25A11 [mitochondrial inner membrane] (R-HSA-198451)	0.556	3
UniProt:P49184 DNASE1L1	2	DNASE1L1 [extracellular region] (R-HSA-6806320) DNASE1L1 [specific granule lumen] (R-HSA-6799554)	0.556	3
UniProt:Q96L03 SPT17			0.556	3
UniProt:Q9H2S6-2 TNMD			0.556	3
UniProt:F6Y2X3 F6Y2X3			0.556	3
UniProt:Q96I25 RBM17	1	RBM17 [nucleoplasm] (R-HSA-8865891)	0.556	3
UniProt:A2RUH7 MBPHL			0.556	3
UniProt:Q9BT49 THAP7			0.556	3
UniProt:Q8N1W1-4 ARHGEF28			0.556	3
UniProt:Q9Y617 PSAT1	1	PXLP-K200-PSAT1 [cytosol] (R-HSA-977330)	0.556	3
UniProt:Q9BQ29 Q9BQ29			0.556	3
UniProt:Q8TB02 Q8TB02			0.556	3
UniProt:P43356 MAGA2			0.556	3
UniProt:Q96JJ7-2 Q96JJ72			0.556	3
UniProt:P14060 HSD3B1	1	HSD3B1 [endoplasmic reticulum membrane] (R-HSA-192072)	0.556	3
UniProt:P79483 HLA-DRB3	9	HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [lumenal side of endoplasmic reticulum membrane] (R-HSA-2130513) HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [ER to Golgi transport vesicle membrane] (R-HSA-2130432) HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [Golgi membrane] (R-HSA-2214381) HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [trans-Golgi network membrane] (R-HSA-2130452) HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [transport vesicle membrane] (R-HSA-2130559) HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [clathrin-coated endocytic vesicle membrane] (R-HSA-2130515) HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [endocytic vesicle membrane] (R-HSA-2130377) HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [lysosomal membrane] (R-HSA-2130676) HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [plasma membrane] (R-HSA-197577)	0.556	3
UniProt:Q6P4D5-2 PABIR3			0.556	3
UniProt:Q6P5S2 LEG1H			0.556	3
UniProt:O75317 USP12	1	USP12 [nucleoplasm] (R-HSA-5696907)	0.556	3
IntAct:EBI-25834143 CCSB			0.556	3
IntAct:EBI-25833532 RZPDO839F06154			0.556	3
UniProt:O75874 IDH1	10	IDH1 R132H mutant [cytosol] (R-HSA-880015) IDH1 R132L mutant [cytosol] (R-HSA-880000) IDH1 R132S mutant [cytosol] (R-HSA-880048) IDH1 R132C mutant [cytosol] (R-HSA-880031) IDH1 [secretory granule lumen] (R-HSA-6800980) IDH1 [ficolin-1-rich granule lumen] (R-HSA-6800977) IDH1 [extracellular region] (R-HSA-6806433) IDH1 [tertiary granule lumen] (R-HSA-6800163) IDH1 [cytosol] (R-HSA-389549) IDH1 [peroxisomal matrix] (R-HSA-389546)	0.556	3
UniProt:Q13636 RAB31	5	GGC-RAB31 [early endosome membrane] (R-HSA-8877278) GGC-RAB31 [cytosol] (R-HSA-8873974) RAB31 [cytosol] (R-HSA-8873690) RAB31 [plasma membrane] (R-HSA-6804813) RAB31 [secretory granule membrane] (R-HSA-6804797)	0.556	3
UniProt:Q8NBT0 POC1A			0.556	3
UniProt:Q96EY8 MMAB	4	MMAB E193K [mitochondrial matrix] (R-HSA-3322150) MMAB R191W [mitochondrial matrix] (R-HSA-3322112) MMAB R186W [mitochondrial matrix] (R-HSA-3322128) MMAB [mitochondrial matrix] (R-HSA-2980970)	0.556	3
UniProt:P49746 THBS3	1	THBS3 [extracellular region] (R-HSA-66522)	0.556	3
UniProt:P48775 TDO2	1	TDO2 [cytosol] (R-HSA-71184)	0.556	3
UniProt:A0JP07 A0JP07			0.556	3
UniProt:O00214-2 LGALS8			0.556	3
UniProt:Q9ULR0 ISY1	1	ISY1 [nucleoplasm] (R-HSA-6781963)	0.556	3
UniProt:Q9Y3Y4 PYGO1	1	PYGO1 [nucleoplasm] (R-HSA-201705)	0.556	3
UniProt:Q96QH2 PRAM			0.556	3
UniProt:O14829 PPEF1	1	PPEF1 [cytosol] (R-HSA-2632517)	0.556	3
UniProt:Q99944 EGFL8			0.556	3
UniProt:Q8NCF5-2 NFATC2IP			0.556	3
UniProt:P50749 RASF2			0.556	3
UniProt:Q8NCR3 MFI			0.556	3
UniProt:P09382 LGALS1	2	p-LGALS1 [endoplasmic reticulum lumen] (R-HSA-8957003) LGALS1 [endoplasmic reticulum lumen] (R-HSA-8956711)	0.556	3
IntAct:EBI-25833762 CCSB			0.556	3
IntAct:EBI-25833683 CCSB			0.556	3
UniProt:Q8IY82 DRC7			0.556	3
UniProt:Q9NPC7 MYNN			0.556	3
UniProt:Q8N323 NXPE1			0.556	3
UniProt:Q6UXH1-2 CRELD2			0.556	3
UniProt:Q7Z6Z7-2 HUWE1			0.556	3
UniProt:P52756 RBM5	1	RBM5 [nucleoplasm] (R-HSA-72049)	0.556	3
UniProt:P61224 RAP1B	2	RAP1B [azurophil granule membrane] (R-HSA-6804972) RAP1B [plasma membrane] (R-HSA-377590)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q13200 PSMD2	5	PSMD2 [secretory granule lumen] (R-HSA-6800919) PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [cytosol] (R-HSA-68796)	0.556	3
UniProt:P16422 EPCAM	1	EPCAM [plasma membrane] (R-HSA-375068)	0.556	3
UniProt:P26715 KLRC1	1	KLRC1 [plasma membrane] (R-HSA-3006545)	0.556	3
UniProt:Q9ULW0 TPX2	2	TPX2 [cytosol] (R-HSA-8853407) TPX2 [nucleoplasm] (R-HSA-2564700)	0.556	3
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.556	3
UniProt:P07437 TUBB	3	TUBB [cytosol] (R-HSA-9020816) TUBB [azurophil granule lumen] (R-HSA-6799370) TUBB [extracellular region] (R-HSA-380317)	0.556	3
UniProt:Q10981 FUT2	1	FUT2 [Golgi membrane] (R-HSA-2980904)	0.556	3
UniProt:Q96P20 NLRP3	2	K63polyUb-NLRP3 [cytosol] (R-HSA-6783288) NLRP3 [cytosol] (R-HSA-561189)	0.556	3
UniProt:Q8N2W9 PIAS4	2	PIAS4 [nucleoplasm] (R-HSA-2993789) monoSUMO1-K35-PIAS4 [nucleoplasm] (R-HSA-3968415)	0.556	3
UniProt:P55209 NP1L1			0.547	3
UniProt:P09622 DLD	8	I47T DLD [mitochondrial matrix] (R-HSA-9907707) D479V DLD [mitochondrial matrix] (R-HSA-9907708) G229C DLD [mitochondrial matrix] (R-HSA-9907709) R495G DLD [mitochondrial matrix] (R-HSA-9907710) E375K DLD [mitochondrial matrix] (R-HSA-9907711) I393T DLD [mitochondrial matrix] (R-HSA-9907713) M361V DLD [mitochondrial matrix] (R-HSA-9907714) DLD [mitochondrial matrix] (R-HSA-69978)	0.527	2
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.499	4
UniProt:P06493 CDK1	11	CDK1 [endoplasmic reticulum membrane] (R-HSA-264424) p-Y4-CDK1 [cytosol] (R-HSA-9836187) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14-CDK1 [cytosol] (R-HSA-170064) CDK1 [nucleoplasm] (R-HSA-68889) CDK1 [cytosol] (R-HSA-170075) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T161-CDK1 [nucleoplasm] (R-HSA-170066)	0.499	3
UniProt:Q9H9B4 SFXN1			0.483	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	8

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