Reactome | FIRRM binds PPP1CC

FIRRM binds PPP1CC

Stable Identifier

R-HSA-9853372

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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The C-terminus of FIRRM (also known as Apolo1 or FLIP or C1orf112) contains a canonical PP1 docking motif KVVSF and binds to PP1gamma (PPP1CC), inhibiting PPP1CC-mediated dephosphorylation of the PLK1 threonine residue T210. The phosphorylation of the RV[S/T]F motifs is a general mechanism for negative control of the interaction of PP1 with its regulatory proteins. The serine residue S744 in the KVVSF motif of FIRRM is highly conserved among different vertebrate species, but overall is the least conserved residue of the KVVSF motif. Phosphorylation of FIRRM at S744 by PLK1 negatively regulates FIRRM binding to PPP1CC (Xu et al. 2021).

Literature References

PubMed ID	Title	Journal	Year
34260926	Feedback control of PLK1 by Apolo1 ensures accurate chromosome segregation Sun, B, Tian, R, Poser, I, Garba, F, Li, L, Liu, X, Green, H, Chu, L, Ge, Y, Dou, Z, Lu, J, Pan, W, Yuan, X, Liu, D, Wang, D, Mullen, M, Duan, W, Duan, H, Ali, M, Hyman, A, Yao, X, Xu, L	Cell Rep	2021