Reactome | FIRRM binds FIGNL1

FIRRM binds FIGNL1

Stable Identifier

R-HSA-9853368

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - Homology Directed Repair (Homo sapiens)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
      - HDR through Homologous Recombination (HRR) (Homo sapiens)
        
        Resolution of D-Loop Structures (Homo sapiens)
        
        Resolution of D-loop Structures through Holliday Junction Intermediates (Homo sapiens)
        
        FIRRM binds FIGNL1 (Homo sapiens)

General

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FIRRM (also known as FLIP, Apolo1, or C1orf112) was initially isolated by tandem affinity purification (TAP) of FIGNL1-interacting proteins from human embryonic kidney cell line 293T (Yuan and Chen 2013). The complex of FIRRM and FIGNL1 was shown to be conserved from Arabidopsis to humans, and FIRRM has been proposed to act as a FIGNL1 adaptor (Fernandes et al. 2018).

Literature References

PubMed ID	Title	Journal	Year
23754376	FIGNL1-containing protein complex is required for efficient homologous recombination repair Chen, J, Yuan, J	Proc Natl Acad Sci U S A	2013
29608566	FIGL1 and its novel partner FLIP form a conserved complex that regulates homologous recombination Andrey, P, Kumar, R, Froger, N, Seguéla-Arnaud, M, Mercier, R, Choinard, S, Gevaert, K, Fernandes, JB, De Winne, N, Solier, V, Girard, C, Duhamel, M, Grelon, M, De Jaeger, G, Guerois, R	PLoS Genet	2018