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Translation of DNMT1 mRNA is repressed by miR-21
Stable Identifier
R-HSA-9851145
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
,
nucleoplasm
ReviewStatus
5/5
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Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by ALK in cancer (Homo sapiens)
Signaling by ALK fusions and activated point mutants (Homo sapiens)
Nuclear events stimulated by ALK signaling in cancer (Homo sapiens)
Translation of DNMT1 mRNA is repressed by miR-21 (Homo sapiens)
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miR-21 represses the translation of DNMT1 mRNA. In the context of NPM1-ALK signaling, DNMT1 contributes to the repression of IL2RG expression through promoter methylation; STAT3 contributes to this repression in two ways, by directly recruiting DNMT1 to the IL2RG promoter, and by downregulating MIR21 gene expression, allowing DNMT1 levels to increase (Zhang et al, 2011).
Literature References
PubMed ID
Title
Journal
Year
21715655
IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK
Wasik, M
,
Liu, X
,
Zhang, Q
,
Kantekure, K
,
Wang, HY
,
Bhutani, G
Proc. Natl. Acad. Sci. U.S.A.
2011
Participants
Input
DNMT1 mRNA [cytosol]
(Homo sapiens)
Output
DNMT1 [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Nuclear events stimulated by ALK signaling in cancer (Homo sapiens)
This event is regulated
Negatively by
Regulator
miR-21 RISC:DNMT1 mRNA [cytosol]
(Homo sapiens)
Active Unit
miR21 RISC [cytosol]
Disease
Name
Identifier
Synonyms
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K (2023-10-14)
Reviewed
Turner, S (2023-11-08)
Created
Rothfels, K (2023-10-12)
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