Translation of DNMT1 mRNA is repressed by miR-21

Stable Identifier
R-HSA-9851145
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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miR-21 represses the translation of DNMT1 mRNA. In the context of NPM1-ALK signaling, DNMT1 contributes to the repression of IL2RG expression through promoter methylation; STAT3 contributes to this repression in two ways, by directly recruiting DNMT1 to the IL2RG promoter, and by downregulating MIR21 gene expression, allowing DNMT1 levels to increase (Zhang et al, 2011).
Literature References
PubMed ID Title Journal Year
21715655 IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK

Wasik, M, Liu, X, Zhang, Q, Kantekure, K, Wang, HY, Bhutani, G

Proc. Natl. Acad. Sci. U.S.A. 2011
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This event is regulated
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
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