NPM1-ALK- and STAT3-dependent TWIST gene expression

Stable Identifier
R-HSA-9851109
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NPM1-ALK- and STAT3-dependent TWIST gene expression
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TWIST is aberrantly upregulated downstream of NPM-ALK in a manner that depends on phosphorylated STAT3; this expression is specific to cancer cell lines as it is not observed in corresponding WT cells (Zhang et al, 2012; Inoue et al, 2017). NPM-ALK may induce TWIST expression through phosphorylated AKT and NF-KB (Inoue et al, 2017). TWIST expression contributes to the invasiveness of NPM-ALK+ ALCL SUP-M2 and SU-DHL-1 cell lines (Zhang et al, 2012).
Literature References
PubMed ID Title Journal Year
28193280 Functional role of ALK-related signal cascades on modulation of epithelial-mesenchymal transition and apoptosis in uterine carcinosarcoma

Hashimura, M, Saegusa, M, Inoue, H, Chiba, R, Akiya, M

Mol Cancer 2017
22155737 Aberrant expression of the transcriptional factor Twist1 promotes invasiveness in ALK-positive anaplastic large cell lymphoma

Wang, P, McMullen, TP, Zhang, J, Ingham, RJ, Li, M, Hitt, M, Wu, F, Sharon, D, Lai, R

Cell Signal 2012
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
Disease
Name Identifier Synonyms
anaplastic large cell lymphoma DOID:0050744
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2023-10-14)
Reviewed
Turner, S  (2023-11-08)
Created
Rothfels, K  (2023-10-12)
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