NPM1-ALK- and STAT3-dependent ICOS gene expression

Stable Identifier
R-HSA-9851104
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
NPM1-ALK- and STAT3-dependent ICOS gene expression
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
ICOS is a member of the CD28 co-stimulatory receptor superfamily that is involved in T-cell responses to a foreign antigen, including proliferation, secretion of lymphokines and regulation of molecules that mediate cell-cell interaction. ICOS is present at the plasma member as a homodimer, where it interacts with its ligand ICOSLG (Hutloff et al, 1999; Beier et al, 2000; reviewed in Solinas et al, 2019). ICOS gene expression is regulated downstream of activated NPM-ALK in a manner that depends on the fusion protein kinase activity and STAT3 (Zhang et al, 2011).
Literature References
PubMed ID Title Journal Year
9930702 ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28

Hutloff, A, Dittrich, AM, Beier, KC, Eljaschewitsch, B, Kraft, R, Anagnostopoulos, I, Kroczek, RA

Nature 1999
11169414 Induction, binding specificity and function of human ICOS

Beier, KC, Hutloff, A, Dittrich, AM, Heuck, C, Rauch, A, Büchner, K, Ludewig, B, Ochs, HD, Mages, HW, Kroczek, RA

Eur J Immunol 2000
21765024 Oncogenic tyrosine kinase NPM-ALK induces expression of the growth-promoting receptor ICOS

Zhang, Q, Wang, H, Kantekure, K, Paterson, JC, Liu, X, Schaffer, A, Paulos, C, Milone, MC, Odum, N, Turner, S, Marafioti, T, Wasik, MA

Blood 2011
32516116 The rationale behind targeting the ICOS-ICOS ligand costimulatory pathway in cancer immunotherapy

Solinas, C, Gu-Trantien, C, Willard-Gallo, K

ESMO Open 2020
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
ICOS gene:p-STAT3 [nucleoplasm] (Homo sapiens)
Active Unit
p-Y705,S727-STAT3 dimer [nucleoplasm]
Disease
Name Identifier Synonyms
anaplastic large cell lymphoma DOID:0050744
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
Mondo
Authored
Rothfels, K  (2023-10-14)
Reviewed
Turner, S  (2023-11-08)
Created
Rothfels, K  (2023-10-12)
Cite Us!