NPM1-ALK- and JUN-dependent CDKN1A gene repression

Stable Identifier
R-HSA-9851098
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NPM1-ALK- and JUN-dependent CDKN1A gene repression
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CDKN1A expression is repressed downstream of NPM1-ALK in a manner that depends on JNK Leventaki et al, 2007; Cui et al, 2009). JNK-mediated repression of CDKN1A may be mediated through JUN or TP53 (Leventaki et al, 2007; Cui et al, 2009). Repression of this cell cycle inhibitor is one way in which NPM1-ALK signaling promotes proliferative growth.
Literature References
PubMed ID Title Journal Year
17416736 NPM-ALK oncogenic kinase promotes cell-cycle progression through activation of JNK/cJun signaling in anaplastic large-cell lymphoma

Drakos, E, Rassidakis, GZ, Elenitoba-Johnson, KS, Lim, MS, Claret, FX, Medeiros, LJ, Leventaki, V

Blood 2007
19286999 NPM-ALK inhibits the p53 tumor suppressor pathway in an MDM2 and JNK-dependent manner

McDuff, FK, Turner, SD, Kerby, A, Ye, H, Cui, YX

Blood 2009
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
p-S63,S73-JUN [nucleoplasm] (Homo sapiens)
Disease
Name Identifier Synonyms
anaplastic large cell lymphoma DOID:0050744
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2023-10-14)
Reviewed
Turner, S  (2023-11-08)
Created
Rothfels, K  (2023-10-12)
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