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AcK685 pY705,S727 STAT3 binds the MIR21 gene
Stable Identifier
R-HSA-9851062
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by ALK in cancer (Homo sapiens)
Signaling by ALK fusions and activated point mutants (Homo sapiens)
Nuclear events stimulated by ALK signaling in cancer (Homo sapiens)
AcK685 pY705,S727 STAT3 binds the MIR21 gene (Homo sapiens)
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STAT3 binds to the MIR21 gene as assessed by chromatin immunoprecipitation (ChIP). STAT3 binding represses expression of miR-21 (Zhang et al, 2011).
Literature References
PubMed ID
Title
Journal
Year
21715655
IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK
Wasik, M
,
Liu, X
,
Zhang, Q
,
Kantekure, K
,
Wang, HY
,
Bhutani, G
Proc. Natl. Acad. Sci. U.S.A.
2011
Participants
Input
AcK685- p-Y705,S727-STAT3 dimer [nucleoplasm]
(Homo sapiens)
MIR21 gene [nucleoplasm]
(Homo sapiens)
Output
MIR21 gene:AcK685-pY705,p-S727 STAT3 dimer [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Nuclear events stimulated by ALK signaling in cancer (Homo sapiens)
Disease
Name
Identifier
Synonyms
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K (2023-10-14)
Reviewed
Turner, S (2023-11-08)
Created
Rothfels, K (2023-10-12)
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