AcK685 pY705,S727 STAT3 binds the MIR21 gene

Stable Identifier
R-HSA-9851062
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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STAT3 binds to the MIR21 gene as assessed by chromatin immunoprecipitation (ChIP). STAT3 binding represses expression of miR-21 (Zhang et al, 2011).
Literature References
PubMed ID Title Journal Year
21715655 IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK

Wasik, M, Liu, X, Zhang, Q, Kantekure, K, Wang, HY, Bhutani, G

Proc. Natl. Acad. Sci. U.S.A. 2011
Participants
Participates
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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