Reactome | Kinesin-3 is a dimer

Kinesin-3 is a dimer

Stable Identifier

R-HSA-984733

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Kinesin-3 drives the transport of synaptic vesicle precursors to axon terminals. Loss of the Caenorhabditis elegans protein Unc104, eqivalent to human KIF1A, results in decreased synaptic vesicles in axonal growth cones. In mice loss of KIF1A caused severe motor and sensory abnormalities associated with neuronal cell death (Yonekawa et al. 1998). Kinesin-3 is often described as monomeric, but has recently been shown to be functionally dimeric (Hammond et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
7528108	KIF1B, a novel microtubule plus end-directed monomeric motor protein for transport of mitochondria Nangaku, M, Sato-Yoshitake, R, Okada, Y, Noda, Y, Takemura, R, Yamazaki, H, Hirokawa, N	Cell	1994
19338388	Mammalian Kinesin-3 motors are dimeric in vivo and move by processive motility upon release of autoinhibition Hammond, JW, Cai, D, Blasius, TL, Li, Z, Jiang, Y, Jih, GT, Meyhofer, E, Verhey, KJ	PLoS Biol	2009
7539720	The neuron-specific kinesin superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursors Okada, Y, Yamazaki, H, Sekine-Aizawa, Y, Hirokawa, N	Cell	1995