The HUSH complex bound to trimethylated histone H3 of retroelement chromatin recruits the NEXT RNA degradation complex (RBM7:ZCCHC8:SKIV2L2) (inferred from mouse homologs in Garland et al. 2022). MPHOSPH8 (MPP8) of the HUSH complex binds ZCCHC8 close to the site on ZCCHC8 bound by SKIV2L2 (MTR4) (inferred from mouse homologs in Garland et al. 2022). NEXT and HUSH cooperate to repress expression of retroelements, with NEXT suppressing shorter, non-polyadenylated transcripts, likely through RNA degradation, and HUSH suppressing full-length polyadenylated transcripts, likely through repression of transcription (inferred from mouse homologs in Garland et al. 2022). The TASOR subunit of the HUSH complex contains a catalytically active PARP domain that is necessary for targeted H3K9me3 deposition and therefore may direct the HUSH complex to genomic targets (Douse et al. 2020).