Mouse lncRNA named Blnc1 (for Brown fat lncRNA 1) is a nuclear lncRNA that was found to promote mouse brown and beige adipocyte differentiation and function. The mouse Blnc1 lncRNA forms a complex with the transcription factor EBF2 and stimulates EBF2-mediated activation of thermogenic genes, such as Ucp1. Blnc1 lncRNA gene also possesses an EBF-binding site in its promoter, and its expression is positively regulated by EBF2, thus creating a positive feedback loop (Zhao et al. 2014). Blnc1 lncRNA is conserved in humans, especially in the RNA domain 1 (RD1) region, which is necessary and sufficient for the interaction with EBF2 and stimulation of the thermogenic gene expression program in brown adipocytes (Mi et al. 2017). Human Blnc1 lncRNA can compensate for mouse Blnc1 lncRNA deficiency in mouse brown preadipocytes. HNRNPU (heterogeneous nuclear ribonucleoprotein U) facilitates the interaction between Blnc1 lncRNA and EBF2 by directly participating in the formation of the EBF2 ribonucleoprotein complex (Mi et al. 2017). The specific expression of Blnc1 lncRNA in mature mouse brown adipocytes was confirmed in Brunmeir et al. 2016.