Reactome | MPHOSPH8 (MPP8) in HUSH complex binds histone H3 trimethyl-lysine 9 (H3K9me3) in L1HS,L1PA2,3 heterochromatin

MPHOSPH8 (MPP8) in HUSH complex binds histone H3 trimethyl-lysine 9 (H3K9me3) in L1HS,L1PA2,3 heterochromatin

Stable Identifier

R-HSA-9844015

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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MPHOSPH8 (MPP8) in HUSH complex binds histone H3 trimethyl-lysine 9 (H3K9me3) in L1HS,L1PA2,3 heterochromatin

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The chromodomain of the MPHOSPH8 (MPP8) subunit of the HUSH complex binds trimethylated lysine-9 of histone H3 (H3K9me3) (Kokura et al. 2010, Li et al. 2011, Tchasovnikarova et al. 2015) and recruits the HUSH complex to existing repressive chromatin (Tchasovnikarova et al. 2015). TASOR serves as the central unit of the HUSH complex by binding both MPHOSPH8 and PPHLN1 (Douse et al. 2020). Periphilin (PPHLN1) binds as a dimer to TASOR (Prigozhin et al. 2020). The HUSH complex binds young L1 elements L1HS, L1PA2, L1PA3 (Liu et al. 2018, Robbez-Masson et al. 2018).

Literature References

PubMed ID	Title	Journal	Year
29211708	Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators Gu, B, Swigut, T, Bassik, MC, Grow, E, Liu, N, Lee, CH, Wysocka, J	Nature	2018
22022377	Structural basis for specific binding of human MPP8 chromodomain to histone H3 methylated at lysine 9 Min, J, Li, J, Zang, J, Tempel, W, Li, Z, Pan, PW, Ruan, J, Tong, Y, Xu, C, Crombet, L	PLoS One	2011
29728366	The HUSH complex cooperates with TRIM28 to repress young retrotransposons and new genes Robbez-Masson, L, Rowe, HM, Conde, L, Timms, RT, Tchasovnikarova, IA, Herrero, J, Tunbak, H, Tie, CHC, Lehner, PJ, Husovsky, C	Genome Res	2018
33009411	TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control Freund, SMV, Seczynska, M, Protasio, AV, Timms, RT, Tchasovnikarova, IA, Modis, Y, Albecka, A, Douse, CH, Prigozhin, DM, Williamson, JC, Wagstaff, J, Lehner, PJ	Nat Commun	2020
20871592	Methyl-H3K9-binding protein MPP8 mediates E-cadherin gene silencing and promotes tumour cell motility and invasion Bedford, MT, Sun, L, Fang, J, Kokura, K	EMBO J	2010
32976585	Periphilin self-association underpins epigenetic silencing by the HUSH complex Oda, SI, Maslen, S, Freund, SMV, Farleigh, LE, Adolf, F, Timms, RT, Tchasovnikarova, IA, Modis, Y, Albecka, A, Douse, CH, Prigozhin, DM, Lehner, PJ	Nucleic Acids Res	2020
26022416	GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells Dougan, G, Timms, RT, Tchasovnikarova, IA, Göttgens, B, Matheson, NJ, Wals, K, Lehner, PJ, Dawson, MA, Antrobus, R	Science	2015