me3-K16-ATF7IP:SETDB1 and MORC2 bind MPHOSPH8 (MPP8) in HUSH complex:L1 RNA

Stable Identifier
R-HSA-9843993
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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me3-K16-ATF7IP:SETDB1 and MORC2 bind MPHOSPH8 (MPP8) in HUSH complex:L1 RNA
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The HUSH complex binds ATF7IP:SETDB1 (Timms et al. 2016) and MORC2 (Tchasovnikarova et al. 2017, Liu et al. 2018). Trimethylation of lysine-16 on ATF7IP is required for interaction with MPHOSPH8 of the HUSH complex (inferred from mouse homologs in Liu et al. 2018). SETDB1 trimethylates histone H3 on lysine-9 (Seczynska et al. 2022) and MORC2 acts to compact chromatin (Tchasovnikarova et al. 2017) at loci bound by the HUSH complex.
Literature References
PubMed ID Title Journal Year
29211708 Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators

Gu, B, Swigut, T, Bassik, MC, Grow, E, Liu, N, Lee, CH, Wysocka, J

Nature 2018
28581500 Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2

Dougan, G, Timms, RT, Tchasovnikarova, IA, Modis, Y, Douse, CH, Kingston, RE, Roberts, RC, Lehner, PJ

Nat Genet 2017
34794168 Genome surveillance by HUSH-mediated silencing of intronless mobile elements

Cuesta, SM, Seczynska, M, Bloor, S, Lehner, PJ

Nature 2022
27732843 ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex

Dougan, G, Tchasovnikarova, IA, Timms, RT, Lehner, PJ, Antrobus, R

Cell Rep 2016
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me3-K16-Atf7ip binds Mphosph8 (Mpp8) (Mus musculus)
Authored
May, B  (2023-09-11)
Reviewed
Bourc'his, D  (2024-05-14)
Fernandes, LP  (2024-05-14)
Created
May, B  (2023-09-12)
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