me3-K16-ATF7IP:SETDB1 and MORC2 bind MPHOSPH8 (MPP8) in HUSH complex:L1HS,L1PA2,3 heterochromatin

Stable Identifier
R-HSA-9843927
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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me3-K16-ATF7IP:SETDB1 and MORC2 bind MPHOSPH8 (MPP8) in HUSH complex:L1HS,L1PA2,3 heterochromatin
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The HUSH complex bound to young L1 retroelements (Liu et al. 2018, Robbez-Masson et al. 2018) recruits both ATP7IP:SETDB1 (Tchasovnikarova et al. 2015) and MORC (Tchasovnikarova et al. 2017). Trimethylated lysine-16 of ATF7IP is required for binding to MPHOSPH8 (MPP8) of the HUSH complex (Robbez-Masson et al. 2018, and inferred from mouse homologs in Tsusaka et al. 2018). SETDB1 trimethylates lysine-9 of histone H3 (H3K9me3, Tchasovnikarova et al. 2015) and the ATP-dependent chromatin remodeler MORC2 acts to compact chromatin (Tchasovnikarova et al. 2017).
Literature References
PubMed ID Title Journal Year
29211708 Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators

Gu, B, Swigut, T, Bassik, MC, Grow, E, Liu, N, Lee, CH, Wysocka, J

Nature 2018
28581500 Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2

Dougan, G, Timms, RT, Tchasovnikarova, IA, Modis, Y, Douse, CH, Kingston, RE, Roberts, RC, Lehner, PJ

Nat Genet 2017
29728366 The HUSH complex cooperates with TRIM28 to repress young retrotransposons and new genes

Robbez-Masson, L, Rowe, HM, Conde, L, Timms, RT, Tchasovnikarova, IA, Herrero, J, Tunbak, H, Tie, CHC, Lehner, PJ, Husovsky, C

Genome Res 2018
26022416 GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells

Dougan, G, Timms, RT, Tchasovnikarova, IA, Göttgens, B, Matheson, NJ, Wals, K, Lehner, PJ, Dawson, MA, Antrobus, R

Science 2015
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me3-K16-Atf7ip binds Mphosph8 (Mpp8) (Mus musculus)
Authored
May, B  (2023-09-11)
Reviewed
Bourc'his, D  (2024-05-14)
Fernandes, LP  (2024-05-14)
Created
May, B  (2023-09-12)
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