Reactome | ATF7IP:SETDB1 binds SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin

ATF7IP:SETDB1 binds SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin

Stable Identifier

R-HSA-9842839

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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ATF7IP:SETDB1 binds SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin

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SETDB1 binds the C-terminal region of TRIM28 (KAP1) which contains the PHD and Bromo domains (Schultz et al. 2002). SETDB1 also binds SUMO2 and the binding depends on lysine residues 33, 42, 35, and 42 of SUMO2 (Rosendorf et al. 2006). In the nucleus, SETDB1 exists in a complex with ATF7IP (hAM, mAM) (inferred from mouse homologs in Tsusaka et al. 2019), which stimulates SETDB1 activity and protects SETDB1 from degradation (Wang et al. 2003, Basavapathruni et al. 2016).

Literature References

PubMed ID	Title	Journal	Year
16567619	NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression Rosendorff, A, Sakakibara, S, Lu, S, Kieff, E, Xuan, Y, DiBacco, A, Shi, Y, Shi, Y, Gill, G	Proc Natl Acad Sci U S A	2006
26813693	Characterization of the Enzymatic Activity of SETDB1 and Its 1:1 Complex with ATF7IP Basavapathruni, A, Gureasko, J, Porter Scott, M, Hermans, W, Godbole, A, Leland, PA, Boriack-Sjodin, PA, Wigle, TJ, Copeland, RA, Riera, TV	Biochemistry	2016
11959841	SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins Schultz, DC, Ayyanathan, K, Negorev, D, Maul, GG, Rauscher, FJ	Genes Dev.	2002
14536086	mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression Wang, H, An, W, Cao, R, Xia, L, Erdjument-Bromage, H, Chatton, B, Tempst, P, Roeder, RG, Zhang, Y	Mol. Cell	2003