IRS1 recruits GRB2 to active LTK

Stable Identifier
R-HSA-9842655
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
3/5
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In the context of a chimeric EGFR:LTK receptor, ligand-dependent autophosphorylation of Y485 appears to support the formation of an IRS1:GRB2 complex that promotes RAS signaling through the activated receptor. These results remain to be validated in the context of a full length LTK receptor with physiological ligand however (Ueno et al, 1995; Ueno et al, 1996).
Literature References
PubMed ID Title Journal Year
8910363 Growth and survival signals transmitted via two distinct NPXY motifs within leukocyte tyrosine kinase, an insulin receptor-related tyrosine kinase

Ueno, H, Sasaki, K, Kozutsumi, H, Miyagawa, K, Mitani, K, Yazaki, Y, Hirai, H

J Biol Chem 1996
7650032 An epidermal growth factor receptor-leukocyte tyrosine kinase chimeric receptor generates ligand-dependent growth signals through the Ras signaling pathway

Ueno, H, Hirano, N, Kozutsumi, H, Sasaki, K, Tanaka, T, Yazaki, Y, Hirai, H

J Biol Chem 1995
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