Reactome | IRS1 recruits GRB2 to active LTK

IRS1 recruits GRB2 to active LTK

Stable Identifier

R-HSA-9842655

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

3/5

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In the context of a chimeric EGFR:LTK receptor, ligand-dependent autophosphorylation of Y485 appears to support the formation of an IRS1:GRB2 complex that promotes RAS signaling through the activated receptor. These results remain to be validated in the context of a full length LTK receptor with physiological ligand however (Ueno et al, 1995; Ueno et al, 1996).

Literature References

PubMed ID	Title	Journal	Year
8910363	Growth and survival signals transmitted via two distinct NPXY motifs within leukocyte tyrosine kinase, an insulin receptor-related tyrosine kinase Ueno, H, Sasaki, K, Kozutsumi, H, Miyagawa, K, Mitani, K, Yazaki, Y, Hirai, H	J Biol Chem	1996
7650032	An epidermal growth factor receptor-leukocyte tyrosine kinase chimeric receptor generates ligand-dependent growth signals through the Ras signaling pathway Ueno, H, Hirano, N, Kozutsumi, H, Sasaki, K, Tanaka, T, Yazaki, Y, Hirai, H	J Biol Chem	1995