Reactome | Active LTK receptor phosphorylates SHC1

Active LTK receptor phosphorylates SHC1

Stable Identifier

R-HSA-9842651

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

3/5

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As suggested by studies using the chimeric EGFR-LTK protein, SHC1 is phosphorylated after recruitment to the activated receptor (Ueno et al, 1995; Ueno et al, 1996). Overexpression of full-length LTK in HEK293 cells also appears to support increased SHC1 phosphorylation relative to vector controls (Roll and Reuther, 2012).

Literature References

PubMed ID	Title	Journal	Year
8910363	Growth and survival signals transmitted via two distinct NPXY motifs within leukocyte tyrosine kinase, an insulin receptor-related tyrosine kinase Ueno, H, Sasaki, K, Kozutsumi, H, Miyagawa, K, Mitani, K, Yazaki, Y, Hirai, H	J Biol Chem	1996
7650032	An epidermal growth factor receptor-leukocyte tyrosine kinase chimeric receptor generates ligand-dependent growth signals through the Ras signaling pathway Ueno, H, Hirano, N, Kozutsumi, H, Sasaki, K, Tanaka, T, Yazaki, Y, Hirai, H	J Biol Chem	1995
22347506	ALK-activating homologous mutations in LTK induce cellular transformation Roll, JD, Reuther, GW	PLoS One	2012