Active LTK receptor binds PI3K

Stable Identifier
R-HSA-9842649
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
3/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Active LTK receptor binds PI3K
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The regulatory p85 subunit of PI3 kinase binds to phosphorylated tyrosine 753 in the intracellular domain of the LTK receptor and recruits the catalytic subunit (shown in one step in this reaction). PI3K signaling contributes to cell survival, possibly through the phosphorylation of S473 of AKT (Ueno et al, 1997; Yamada et al, 2008).
Literature References
PubMed ID Title Journal Year
9223670 The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase

Yazaki, Y, Mitani, K, Honda, H, Yamagata, T, Miyagawa, K, Hirai, H, Sasaki, K, Nakamoto, T, Ueno, H

Oncogene 1997
18849880 Expression of a chimeric CSF1R-LTK mediates ligand-dependent neurite outgrowth

Nomura, T, Takano, K, Miyake, J, Fujita, S, Yamada, S, Miyake, M

Neuroreport 2008
Participants
Input
Output
Participates
as an event of
Orthologous Events
Active LTK receptor binds PI3K (Danio rerio)
Active LTK receptor binds PI3K (Gallus gallus)
Active LTK receptor binds PI3K (Mus musculus)
Active LTK receptor binds PI3K (Rattus norvegicus)
Active LTK receptor binds PI3K (Xenopus tropicalis)
Authored
Rothfels, K  (2023-10-14)
Created
Rothfels, K  (2023-08-27)
Cite Us!