Active LTK receptor binds PI3K

Stable Identifier
R-HSA-9842649
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
3/5
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Active LTK receptor binds PI3K
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The regulatory p85 subunit of PI3 kinase binds to phosphorylated tyrosine 753 in the intracellular domain of the LTK receptor and recruits the catalytic subunit (shown in one step in this reaction). PI3K signaling contributes to cell survival, possibly through the phosphorylation of S473 of AKT (Ueno et al, 1997; Yamada et al, 2008).
Literature References
PubMed ID Title Journal Year
9223670 The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase

Ueno, H, Honda, H, Nakamoto, T, Yamagata, T, Sasaki, K, Miyagawa, K, Mitani, K, Yazaki, Y, Hirai, H

Oncogene 1997
18849880 Expression of a chimeric CSF1R-LTK mediates ligand-dependent neurite outgrowth

Yamada, S, Nomura, T, Takano, K, Fujita, S, Miyake, M, Miyake, J

Neuroreport 2008
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Authored
Rothfels, K  (2023-10-14)
Created
Rothfels, K  (2023-08-27)
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