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TNK2 [cytosol]
Stable Identifier
R-HSA-9842568
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Activated CDC42 kinase 1, ACK1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by LTK (Homo sapiens)
Active LTK binds GRB2:TNK2 (Homo sapiens)
Active LTK:GRB2:TNK2 [plasma membrane] (Homo sapiens)
GRB2:TNK2 [cytosol] (Homo sapiens)
TNK2 [cytosol] (Homo sapiens)
GRB2:TNK2 [cytosol] (Homo sapiens)
TNK2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q07912 TNK2
Gene Names
TNK2, ACK1
Chain
chain:1-1038
Reference Genes
COSMIC (genes):TNK2 TNK2
dbSNP Gene:10188 TNK2
ENSEMBL:ENSG00000061938 TNK2
Participates
as a component of
GRB2:TNK2 [cytosol] (Homo sapiens)
Inferred To
ripk1 [cytosol]
(Xenopus tropicalis)
TNK2 [cytosol]
(Gallus gallus)
TNK2 [cytosol]
(Mus musculus)
TNK2 [cytosol]
(Rattus norvegicus)
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.737
5
UniProt:P16333 NCK1
2
NCK1 [plasma membrane]
(R-HSA-202992)
NCK1 [cytosol]
(R-HSA-197954)
0.688
3
UniProt:P08238 HSP90AB1
6
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
0.564
3
UniProt:Q7Z3S9 NOTCH2NLA
3
NOTCH2NLA [extracellular region]
(R-HSA-9908935)
NOTCH2NLA(1-?) [extracellular region]
(R-HSA-9911493)
NOTCH2NLA(?-236) [extracellular region]
(R-HSA-9911490)
0.556
3
UniProt:P07902 GALT
4
GALT Q188R [cytosol]
(R-HSA-5610008)
GALT K285N [cytosol]
(R-HSA-5610009)
GALT S135L [cytosol]
(R-HSA-5610004)
GALT [cytosol]
(R-HSA-70356)
0.556
3
UniProt:P56945 BCAR1
4
BCAR1 [cytosol]
(R-HSA-201625)
p-Y165,Y664-BCAR1 [cytosol]
(R-HSA-8848723)
p-Y12-BCAR1 [cytosol]
(R-HSA-5218739)
p-Y-BCAR1 [cytosol]
(R-HSA-372645)
0.524
5
UniProt:Q8WXH5 SOCS4
1
SOCS4 [cytosol]
(R-HSA-8936109)
0.488
2
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