Reactome | PSAP(195-273) dimer binds PE

PSAP(195-273) dimer binds PE

Stable Identifier

R-HSA-9842115

Type

Reaction [transition]

Species

Homo sapiens

Compartment

lysosomal lumen, multivesicular body, internal vesicle membrane

ReviewStatus

5/5

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By encapsulating phosphatidylethanolamines (PE) of different sizes from the membrane of intralysosomal luminal vesicles (ILV), the Saposin B (PSAP(195-273) dimer can solubilize relatively large lipid ligands from these membranes (Ahn et al., 2003).

Literature References

PubMed ID	Title	Journal	Year
12518053	Crystal structure of saposin B reveals a dimeric shell for lipid binding Ahn, VE, Faull, KF, Whitelegge, JP, Fluharty, AL, Privé, GG	Proc Natl Acad Sci U S A	2003