ABL1 binds PPARG2

Stable Identifier
R-HSA-9842028
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
3/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
ABL1 binds PPARG2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Activated ABL1 binds to PPARG isoform PPARG2 through an evolutionarily conserved PxxP motif located between amino acids 9-12 in the AF1 domain portion present only in the PPARG2 isoform (Keshet et al. 2014).
Literature References
PubMed ID Title Journal Year
25368164 c-Abl tyrosine kinase promotes adipocyte differentiation by targeting PPAR-gamma 2

Adler, J, Shaul, Y, Reuven, N, Keshet, R, Bryansker Kraitshtein, Z, Shanzer, M

Proc Natl Acad Sci U S A 2014
Participants
Input
Output
Participates
as an event of
Orthologous Events
ABL1 binds PPARG2 (Bos taurus)
ABL1 binds PPARG2 (Caenorhabditis elegans)
ABL1 binds PPARG2 (Canis familiaris)
ABL1 binds PPARG2 (Drosophila melanogaster)
ABL1 binds PPARG2 (Gallus gallus)
ABL1 binds PPARG2 (Mus musculus)
ABL1 binds PPARG2 (Rattus norvegicus)
ABL1 binds PPARG2 (Sus scrofa)
Authored
Orlic-Milacic, M  (2023-08-16)
Created
Orlic-Milacic, M  (2023-08-16)
Cite Us!