Reactome | FOXO3(?-673) [mitochondrial matrix]

FOXO3(?-673) [mitochondrial matrix]

Stable Identifier

R-HSA-9841824

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

fullName evidence="26"Forkhead box protein O3, FOXO3_HUMAN

Icon

Locations in the PathwayBrowser for interactor UniProt:Q92974 ARHGEF2

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Literature References

PubMed ID	Title	Journal	Year
18781224	SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression Leclerc, J, Jacobs, KM, Gius, D, Sun, L, Deng, CX, Spitz, DR, Ahn, BH, Aykin-Burns, N, Mishra, M, Pennington, JD, Bisht, KS, Nguyen, P, Kim, HS	Int J Biol Sci	2008
29445193	Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy Peserico, A, Simone, C, Tezil, T, Scialpi, N, Celestini, V, Russo, L, Signorile, A, Terao, M, Lepore Signorile, M, Garattini, E, Longo, G, Villani, G, Fasano, C, De Rasmo, D, Grossi, V, Gadaleta, RM, Cocco, T, Moschetta, A, Forte, G, Sanese, P	Cell Death Dis	2018
23283301	A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels Peserico, A, Simone, C, Simonatto, M, Fusella, A, Sartorelli, V, Finley, LW, Chiacchiera, F, Matrone, A, Villani, G, Latorre, D, Grossi, V, Ryall, JG, Puri, PL, Haigis, MC	Cell Mol Life Sci	2013

External Reference Information

External Reference

UniProt:O43524 FOXO3

Gene Names

FOXO3, FKHRL1, FOXO3A

Chain

chain:1-673

Reference Genes

BioGPS Gene:2309 FOXO3

COSMIC (genes):FOXO3 FOXO3

CTD Gene:2309 FOXO3

dbSNP Gene:2309 FOXO3

ENSEMBL:ENSG00000118689 FOXO3

ENSEMBL_homo_sapiens_GENE:ENSG00000118689.15 FOXO3

HGNC:3821 FOXO3

KEGG Gene (Homo sapiens):2309 FOXO3

Monarch:2309 FOXO3

NCBI Gene:2309 FOXO3

OMIM:602681 FOXO3

UCSC:O43524 FOXO3

Reference Transcript

Other Identifiers

11718890_x_at

11718891_s_at

11718892_s_at

11737906_x_at

11746522_s_at

11746523_x_at

11749812_s_at

11755663_s_at

204131_PM_s_at

204131_s_at

204132_PM_s_at

204132_s_at

210655_PM_s_at

210655_s_at

217399_3p_s_at

217399_PM_s_at

217399_s_at

224889_3p_at

224889_PM_at

224889_at

224891_PM_at

224891_at

2309

2920476

2920477

2920478

2920479

2920480

2920481

2920482

2920483

2920484

2920485

2920486

2920537

2920538

2920541

2920542

2920543

2920556

2920567

2920568

2920570

2920572

2920574

2920575

34740_at

3748537

3748538

3748557

3748558

3748560

3748563

3748564

3748565

3748566

3748567

3748568

3748569

3748570

47893_s_at

49469_at

49651_at

8013307

8121365

A_23_P345575

A_32_P102062

A_33_P3240392

A_33_P3375665

GE54251

GE85764

GO:0000122

GO:0000785

GO:0000976

GO:0000978

GO:0000981

GO:0001221

GO:0001227

GO:0001228

GO:0001542

GO:0001544

GO:0001547

GO:0001556

GO:0002376

GO:0003012

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005739

GO:0005741

GO:0005759

GO:0005829

GO:0006351

GO:0006355

GO:0006357

GO:0006390

GO:0006417

GO:0006914

GO:0006915

GO:0007155

GO:0008013

GO:0009410

GO:0010508

GO:0012501

GO:0014737

GO:0016020

GO:0019901

GO:0022414

GO:0023052

GO:0030154

GO:0030330

GO:0030336

GO:0031490

GO:0031667

GO:0032991

GO:0033209

GO:0034246

GO:0034599

GO:0042149

GO:0042593

GO:0042594

GO:0043065

GO:0043226

GO:0043525

GO:0043565

GO:0045591

GO:0045648

GO:0045665

GO:0045893

GO:0045944

GO:0048854

GO:0048856

GO:0048870

GO:0060070

GO:0070542

GO:0071333

GO:0071386

GO:0071456

GO:0071548

GO:0090090

GO:0090571

GO:0097150

GO:0097192

GO:0140053

GO:0140110

GO:1901300

GO:1902895

GO:1903428

GO:1904646

GO:1990090

GO:1990785

GO:1990837

GO:2000177

GO:2000353

GO:2000377

HMNXSV003035668

Hs.14845.0.A2_3p_a_at

Hs.214783.0.S1_3p_at

Hs.214783.0.S1_3p_x_at

Hs.214783.0.S2_3p_at

Hs.274468.0.S1_3p_s_at

ILMN_1681703

ILMN_1687940

ILMN_1712515

ILMN_1844692

PH_hs_0028777

PH_hs_0033951

TC06000868.hg

TC06002977.hg

g4106722_3p_a_at

Participates

as an input of

FOXO3 translocates from the mitochondrial matrix to the nucleus (Homo sapiens)

as an output of

SIRT3 deacetylates Ac-K272,K290-FOXO3 (Homo sapiens)

Other forms of this molecule

p-S215 FOXO3 [nucleoplasm]

p-S215 FOXO3 [cytosol]

FOXO3 [cytosol]

p-S43,S173,S294,S325-FOXO3 [nucleoplasm]

p-S43,S173,S294,S325-FOXO3 [cytosol]

Ac-K271,K290-FOXO3(?-673) [mitochondrial matrix]

Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm]

p-T32,S253,S315-FOXO3 [cytosol]

p-T32,S253,S315-FOXO3 [nucleoplasm]

FOXO3 [nucleoplasm]

Inferred To

Foxo3 [mitochondrial matrix] (Mus musculus)

Foxo3 [mitochondrial matrix] (Rattus norvegicus)

foxo3 [mitochondrial matrix] (Xenopus tropicalis)

daf-16 [mitochondrial matrix] (Caenorhabditis elegans)

foxo3b [mitochondrial matrix] (Danio rerio)

FOXO3 [mitochondrial matrix] (Bos taurus)

FOXO3 [mitochondrial matrix] (Canis familiaris)

FOXO3 [mitochondrial matrix] (Gallus gallus)

FOXO3 [mitochondrial matrix] (Sus scrofa)

foxo [mitochondrial matrix] (Drosophila melanogaster)

Cross References

RefSeq

XP_016866075.1, XP_005266925.1, XP_011533931.1, NP_001446.1, NP_963853.1, XP_011533930.1

OpenTargets

ENSG00000118689

HPA

ENSG00000118689-FOXO3

GeneCards

O43524

Ensembl

ENSP00000446316, ENST00000406360, ENSP00000339527, ENSP00000385824, ENST00000343882, ENST00000540898, ENSG00000118689

PRO

O43524

Pharos - Targets

O43524

PDB

6MNL, 7V9B, 2UZK, 2K86, 2LQH, 2LQI

Interactors (29)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.851	6
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.774	6
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.774	6
UniProt:Q13485 SMAD4	20	SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622)	0.743	9
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.706	5
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.704	5
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.695	5
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 [cytosol] (R-HSA-9841264) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357)	0.692	3
UniProt:P84022 SMAD3	20	Ub-SMAD3 [cytosol] (R-HSA-6782830) p-S423,S425-SMAD3 D258N [cytosol] (R-HSA-3315470) p-S423,S425-SMAD3 R268C [cytosol] (R-HSA-3315075) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080) SMAD3 Q316* [cytosol] (R-HSA-9668765) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 S425C [cytosol] (R-HSA-3308499) p-S208-SMAD3 [cytosol] (R-HSA-9731114) SMAD3 [nucleoplasm] (R-HSA-206150) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-9773841) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471)	0.667	5
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.632	7
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.615	3
UniProt:Q92731 ESR2	5	PalmS-ESR2 [cytosol] (R-HSA-9020979) Me-PalmS-ESR2 [plasma membrane] (R-HSA-9637787) PalmS-ESR2 [plasma membrane] (R-HSA-9021059) ESR2 [nucleoplasm] (R-HSA-446165) ESR2 [cytosol] (R-HSA-9020970)	0.591	4
IntAct:EBI-1767788 BIM			0.59	2
UniProt:Q92793 CREBBP	4	monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877) FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) CREBBP [cytosol] (R-HSA-9756493) CREBBP [nucleoplasm] (R-HSA-193545)	0.564	3
UniProt:Q60987 Foxg1	2	Foxg1 [nucleoplasm] (R-MMU-9022630) Foxg1 [nucleoplasm] (R-MMU-9022629)	0.544	5
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.536	2
IntAct:EBI-1657542 ERALPHA			0.527	2
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.524	3
UniProt:P28749 RBL1	2	RBL1 [nucleoplasm] (R-HSA-389104) p-T369,S640,S964,S975-RBL1 [nucleoplasm] (R-HSA-1226085)	0.499	3
UniProt:P30260 CDC27	2	CDC27 [nucleoplasm] (R-HSA-174175) CDC27 [cytosol] (R-HSA-174073)	0.499	2
UniProt:P85037 FOXK1	1	FOXK1 [nucleoplasm] (R-HSA-5689673)	0.499	2
UniProt:Q92974 ARHGEF2	1	ARHGEF2 [cytosol] (R-HSA-195101)	0.499	2
UniProt:Q96T60 PNKP	1	PNKP [nucleoplasm] (R-HSA-5649651)	0.499	2
UniProt:O75529 TAF5L	1	TAF5L [nucleoplasm] (R-HSA-212336)	0.499	2
UniProt:P06400 RB1	20	RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288)	0.499	2
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.471	3
UniProt:P30153 PPP2R1A	2	PPP2R1A [nucleoplasm] (R-HSA-165968) PPP2R1A [cytosol] (R-HSA-165982)	0.462	2
IntAct:EBI-2891650 CDKN1B			0.462	2
IntAct:EBI-2678752 ANDR			0.462	2

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