Reactome | p-S167-ESR1 translocates from the cytosol to the nucleus

p-S167-ESR1 translocates from the cytosol to the nucleus

Stable Identifier

R-HSA-9841817

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, nucleoplasm

ReviewStatus

3/5

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p-S167-ESR1 translocates from the cytosol to the nucleus

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Phosphorylated estrogen receptor alpha (ESR1) translocates from the cytosol to the nucleus, where it activates expression of HTRA2, a protease in the mitochondrial intermembrane space, and NRF1, a regulator of genes encoding components of the oxidative respiratory chain (Papa and Germain 2011). Phosphorylated ESR1 also causes increased activity of the proteasome (Papa and Germain 2011). Phosphorylated ESR1 is able to activate transcription in the absence of its ligand, estrogen (Campbell et al. 2001). Evidence from expression of mutant SOD1 in mice indicates that the ESR1 pathway of the mtUPR is stronger in females than in males and may account for some sex-specific differences in phenotypes (Riar et al. 2017).

Literature References

PubMed ID	Title	Journal	Year
11139588	Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance Patel, NM, Nakshatri, H, Ali, S, Campbell, RA, Constantinidou, D, Bhat-Nakshatri, P	J Biol Chem	2001
21486948	Estrogen receptor mediates a distinct mitochondrial unfolded protein response Papa, L, Germain, D	J Cell Sci	2011