Reactome | OMA1 hydrolyzes YME1L1

OMA1 hydrolyzes YME1L1

Stable Identifier

R-HSA-9840564

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

mitochondrial inner membrane, mitochondrial intermembrane space

ReviewStatus

5/5

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Depletion of ATP and depolarization of the mitochondrial inner membrane cause degradation of YME1L1 by OMA1 (Rainbolt et al. 2015, Rainbolt et al. 2016). Oxidative stress, such as hydrogen peroxide, alters the conformation of YME1L1 which may render it susceptible to degradation by OMA1 (Brambley et al. 2019). Depolarization of the mitochondrial inner membrane also causes YME1L1 to reciprocally degrade OMA1 (Rainbolt et al. 2016).

Literature References

PubMed ID	Title	Journal	Year
25433032	YME1L degradation reduces mitochondrial proteolytic capacity during oxidative stress Wiseman, RL, Saunders, JM, Rainbolt, TK	EMBO Rep	2015
26923599	Reciprocal Degradation of YME1L and OMA1 Adapts Mitochondrial Proteolytic Activity during Stress Wiseman, RL, Puchades, C, Rainbolt, TK, Lebeau, J	Cell Rep	2016