Reactome | PSAP(195-273) dimer:PE binds and mobilizes ligands

PSAP(195-273) dimer:PE binds and mobilizes ligands

Stable Identifier

R-HSA-9840470

Type

Reaction [transition]

Species

Homo sapiens

Compartment

lysosomal lumen, multivesicular body, internal vesicle membrane

ReviewStatus

5/5

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PSAP(195-273) dimer:PE binds and mobilizes ligands

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By encapsulating phosphatidylethanolamines (PE) of different sizes from the membrane of intralysosomal luminal vesicles (ILV), the Saposin B (PSAP(195-273) dimer can solubilize relatively large lipid ligands from these membranes. Ligands carried by Saposin B include GM1, GM3, Gb3, SM4s, Ga2Cer, and LacCer (Vogel et al., 1991; Wilkening et al., 2000; Ahn et al., 2003; reviewed by Sandhoff & Sandhoff, 2018).

Literature References

PubMed ID	Title	Journal	Year
29802621	Emerging concepts of ganglioside metabolism Sandhoff, R, Sandhoff, K	FEBS Lett	2018
10942779	Degradation of membrane-bound ganglioside GM1. Stimulation by bis(monoacylglycero)phosphate and the activator proteins SAP-B and GM2-AP Wilkening, G, Linke, T, Uhlhorn-Dierks, G, Sandhoff, K	J Biol Chem	2000
1889421	Glycosphingolipid specificity of the human sulfatide activator protein Vogel, A, Sandhoff, K, Schwarzmann, G	Eur J Biochem	1991
12518053	Crystal structure of saposin B reveals a dimeric shell for lipid binding Fluharty, AL, Ahn, VE, Privé, GG, Faull, KF, Whitelegge, JP	Proc Natl Acad Sci U S A	2003