Reactome | DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha)

DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha)

Stable Identifier

R-HSA-9840415

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha)

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The interaction between the C-terminal fragment of DELE1 and EIF2AK1 (HRI) enhances the phosphorylation of EIF2S1 by EIF2AK1 (Fessler et al. 2020, Guo et al. 2020, Cheng et al. 2022) apparently by increasing the autophosphorylation of EIF2AK1 (Fessler et al. 2020, Cheng et al. 2022). EIF2S1 is a subunit of the EIF2alpha complex, which participates in translation initiation. Phosphorylation of EIF2S1 inhibits general translation but increases translation of specific mRNAs such as DDIT3 (CHOP) and ATF4, that have upstream open reading frames (Fessler et al. 2020, Guo et al. 2020, Cheng et al. 2022).

Literature References

PubMed ID	Title	Journal	Year
32132707	Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway Unger, BA, Tian, R, Liu, Y, Xu, K, Lin, YT, Guo, X, Kampmann, M, Correia, MA, Wiita, AP, Aviles, G	Nature	2020
32132706	A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol Schmitt, S, Mancilla, IA, Fessler, E, Meyer-Bender, MF, Jae, LT, Eckl, EM, Philippou-Massier, J, Zischka, H, Krebs, S, Hanf, M	Nature	2020
35163244	The Mitochondrial PHB2/OMA1/DELE1 Pathway Cooperates with Endoplasmic Reticulum Stress to Facilitate the Response to Chemotherapeutics in Ovarian Cancer Wang, B, Kong, Q, Sun, L, Dong, D, Yu, H, Cheng, M, Shen, L	Int J Mol Sci	2022