Reactome | DELE1 [mitochondrial inner membrane]

DELE1 [mitochondrial inner membrane]

Stable Identifier

R-HSA-9840377

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

fullName evidence="12"DAP3-binding cell death enhancer 1, DELE1_HUMAN

Icon

Locations in the PathwayBrowser for interactor UniProt:Q13449 LSAMP

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Literature References

PubMed ID	Title	Journal	Year
32132707	Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway Guo, X, Aviles, G, Liu, Y, Tian, R, Unger, BA, Lin, YT, Wiita, AP, Xu, K, Correia, MA, Kampmann, M	Nature	2020

External Reference Information

External Reference

UniProt:Q14154 DELE1

Gene Names

DELE1, DELE, KIAA0141

Chain

transit peptide:1-23, propeptide:24-101, chain:102-515, chain:143-515

Reference Genes

BioGPS Gene:9812 DELE1

COSMIC (genes):DELE1 DELE1

CTD Gene:9812 DELE1

dbSNP Gene:9812 DELE1

ENSEMBL:ENSG00000081791 DELE1

HGNC:28969 DELE1

KEGG:hsa:9812 DELE1

Monarch:9812 DELE1

NCBI Gene:9812 DELE1

OMIM:615741 DELE1

UCSC:Q14154 DELE1

Reference Transcript

Other Identifiers

11717031_a_at

11717032_at

11717033_a_at

11717034_a_at

11717035_s_at

16990401

201977_PM_s_at

201977_s_at

201978_PM_s_at

201978_s_at

227056_PM_at

227056_at

238659_PM_at

238659_at

2832966

2832967

2832968

2832969

2832970

2832971

2832972

2832974

2832975

2832978

2832979

2832980

2832983

2832985

2832986

2832987

2832988

2832989

2832990

2832991

2832992

2832995

2832996

2832997

2832998

2832999

2833000

2833001

2833002

2833003

2833004

2833005

2833006

2833007

2833008

2833009

2833010

2833011

2833013

35744_at

48358_at

65143_at

8108832

9812

A_14_P102723

A_23_P213369

A_24_P63563

D50931_at

GE57261

GE783541

GO:0000423

GO:0005515

GO:0005737

GO:0005739

GO:0005741

GO:0005743

GO:0005829

GO:0006413

GO:0006914

GO:0006915

GO:0006974

GO:0008625

GO:0016020

GO:0033554

GO:0043539

GO:0070585

GO:0098772

GO:0140468

GO:1901526

GO:1990641

HMNXSV003010980

HMNXSV003029377

HMNXSV003038962

Hs.63510.0.A1_3p_a_at

Hs.63510.1.A1_3p_at

Hs.92418.0.A1_3p_at

Hs.92418.0.A1_3p_x_at

ILMN_1762990

ILMN_1881299

PH_hs_0023064

TC05000775.hg

g7661939_3p_a_at

Participates

as an input of

OMA1 cleaves DELE1 (Homo sapiens)

Other forms of this molecule

DELE1(143-515) [cytosol]

DELE1(143-515) [mitochondrial inner membrane]

Inferred To

Dele1 [mitochondrial inner membrane] (Mus musculus)

Dele1 [mitochondrial inner membrane] (Rattus norvegicus)

DELE [mitochondrial inner membrane] (Gallus gallus)

DELE1 [mitochondrial inner membrane] (Bos taurus)

DELE1 [mitochondrial inner membrane] (Canis familiaris)

DELE1 [mitochondrial inner membrane] (Sus scrofa)

dele1 [mitochondrial inner membrane] (Danio rerio)

dele1 [mitochondrial inner membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001136075.1, XP_005268605.1, NP_055588.3, XP_005268604.1, XP_054209887.1

ENSEMBL

ENSP00000194118, ENST00000432126, ENSP00000396225, ENSG00000081791, ENST00000194118

OpenTargets

ENSG00000081791

GeneCards

DELE1

HPA

ENSG00000081791-DELE1

PRO

Q14154

Pharos - Targets

Q14154

PDB

8D9X

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13449 LSAMP	2	cleaved GPI-LSAMP [extracellular region] (R-HSA-8941032) GPI-LSAMP [plasma membrane] (R-HSA-8940809)	0.556	3
UniProt:O14656-2 TOR1A			0.556	3
UniProt:Q9BVL2 NUP58			0.556	3
UniProt:P50570-2 DNM2			0.556	3
UniProt:P24539 ATP5PB	1	ATP5PB [mitochondrial inner membrane] (R-HSA-164537)	0.556	3
UniProt:P28331-2 NDUFS1			0.556	3
UniProt:O14901 KLF11			0.556	3
IntAct:EBI-25865403 EHD27213144			0.556	3
UniProt:O43186 CRX			0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	18
UniProt:P15056 BRAF	20	p-S,T-BRAF [cytosol] (R-HSA-169856) BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620)	0.527	2

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