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TGFBR3 binding to GIPC1
Stable Identifier
R-HSA-9839402
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytoplasmic side of plasma membrane
ReviewStatus
3/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGFBR3 (Homo sapiens)
TGFBR3 regulates TGF-beta signaling (Homo sapiens)
TGFBR3 binding to GIPC1 (Homo sapiens)
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Type III TGF β receptor (TGFBR3) binds to GIPC1 at a Class I PDZ binding motif in the cytoplasmic domain of TGFBR3 and prevent TGFBR3 degradation resulting in enhanced expression at plasma membrane (Blobe et al., 2001).
Literature References
PubMed ID
Title
Journal
Year
11546783
A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC
Lodish, HF
,
Blobe, GC
,
How, T
,
Liu, X
,
Fang, SJ
J Biol Chem
2001
Participants
Input
GIPC1 [cytoplasm]
(Homo sapiens)
TGFB1,TGFB2:TGFBR3 [plasma membrane]
(Homo sapiens)
Output
TGFB1,TGFB2:TGFBR3:GIPC1 [cytoplasmic side of plasma membrane]
(Homo sapiens)
Participates
as an event of
TGFBR3 regulates TGF-beta signaling (Homo sapiens)
Orthologous Events
TGFBR3 binding to GIPC1 (Canis familiaris)
TGFBR3 binding to GIPC1 (Danio rerio)
TGFBR3 binding to GIPC1 (Gallus gallus)
TGFBR3 binding to GIPC1 (Mus musculus)
TGFBR3 binding to GIPC1 (Rattus norvegicus)
TGFBR3 binding to GIPC1 (Sus scrofa)
TGFBR3 binding to GIPC1 (Xenopus tropicalis)
Authored
Tiwari, K (2023-07-25)
Created
Tiwari, K (2023-07-05)
© 2025
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